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Y. Takeuchi
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P1.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 209)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.02-005 - Impact of Postoperative Complications on Cancer Recurrence following Lung Cancer Surgery (ID 477)
09:30 - 09:30 | Author(s): Y. Takeuchi
- Abstract
Background:
Recent studies indicate that postoperative complications after various types of cancer surgery are associated with poor cancer-specific survival. Postoperative complications induce severe inflammatory reaction during the perioperative period. Emerging evidence suggests that systemic inflammation can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, which is the first step of extravasation in hematogenous metastasis. The objective of this study was to investigate the impact of postoperative cardiopulmonary complications on cancer recurrence after lung cancer surgery.
Methods:
From a prospective database of 675 consecutive patients who underwent a lung cancer surgery between April 2007 and March 2012, we retrospectively analyzed medical charts of all patients with curative surgery. The primary endpoint was the incidence of cancer recurrence after surgery between the patients with and without postoperative cardiopulmonary complications. Perioperative white blood cell counts and C-reactive protein levels were also compared.
Results:
Postoperative cardiovascular or respiratory complications were identified in 98 (15%) or 30 (4%) patients, respectively. There were no significant differences in the incidence of cancer recurrence between the patients with postoperative cardiovascular complications and without cardiopulmonary complications (23% vs. 19%; p = 0.26). In contrast, there was significantly higher incidence of cancer recurrence in those with postoperative respiratory complications than those without cardiopulmonary complications (42% vs. 19%; p < 0.05). Multiple regression analysis adjusted age, sex, and pathological staging showed the similar tendency, however there was no significant difference. There were significantly higher levels of white blood cell counts and C-reactive protein levels in the acute phase after surgery in those with postoperative respiratory complications than those without. Figure 1
Conclusion:
Not cardiovascular but respiratory complications following lung cancer surgery might have the negative predictor in the incidence of cancer recurrence. Severe inflammation induced by postoperative complications might be associated with high incidence of cancer recurrence.
