Author of

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  P1.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 209)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Localized Disease - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13510

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    P1.02-002 - Interstitial Lung Disease (ILD) Associated Cancer Genesis Is Noble Predictor for Patients with Non-Small Cell Lung Cancer and ILD (ID 578)

    09:30 - 09:30  |  Author(s): H. Ishikawa
    • Abstract
    • Slides

    Background:
    Interstitial lung diseases (ILDs) are at increased risk of developing lung cancer. The purpose of this study is to evaluate the survival and predictors of survival after surgical resection in patients with non-small cell lung cancer (NSCLC) and ILDs.
    
    Methods:
    We retrospectively analyzed data from 55 patients with NSCLC with a clinical diagnosis of ILD who underwent pulmonary resection between 1994 and 2010 at our institution. Kaplan-Meier analysis and Cox proportional hazards regression analysis were used.
    
    Results:
    Male patients (94.5%) and smokers (98.2%) were in majority. The overall 5-year survival was 15.4%. The 5-year survivals were 9.1% and 31.6% for patients with a predicted percent vital capacity of 80% or less and a predicted percent vital capacity greater than 80%, respectively (log-rank test, P = .036). The 5-year survival of patients in which NSCLC was developed in the ILD positive background was 15.4%. On the other hand, the 5-year survival of patients in which NSCLC was developed in the ILD negative background was 47.5% (P = .033). Surgical procedures had an association with survival (P = .051), the 5-year survival were 0% and 31.3% in the wedge resection and segmentectomy / lobectomy groups, respectively. Multivariable analysis revealed that lower predicted percent vital capacity, ILD-associated cancer genesis, and non-anatomical pulmonary resection were independent poor prognostic factor for survival. Carbon monoxide diffusing capacity and Krebs von den Lungen-6 (KL-6) were not included in the analysis because of missing data more than 5%.
    
    Conclusion:
    Anatomical resection is recommended for patients with NSCLC and ILD with predicted percent vital capacity greater than 80%. ILD-associated cancer genesis is noble predictor for patients with a clinical diagnosis of ILD who underwent pulmonary resection for NSCLC.
    
    

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