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J.W. Martinez
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P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.01-028 - Pathological Characteristics of Lung Cancer Patients in Colombian Coffe Zone (ID 3147)
09:30 - 09:30 | Author(s): J.W. Martinez
- Abstract
Background:
During 1998 and 2013 at the “Colombian Coffee Zone” (conformed by three states Caldas, Quindio, and Risaralda) had an increase of 105 mortality cases of Bronchi and lung malignant tumors, as reported in death certificates.
Methods:
This is an observational, descriptive study, that was made in patients at Clínica Oncologos del Occidente in the year 2014. Information was taken from the Clinical History Administration System (SAHICO). Thereafter, pending data was collected, by phone calls to patients or patient’s family, according to every case. Patients were interviewed to know their actual performance status and, in case of death, date and basic cause of death was asked
Results:
SAHICO reported 178 patients with lung cancer. From these patients, 33 did not have a correct diagnosis. Basically, they did not have a histology report. This happens in patients that consulted with a clinical presentation compatible with a pulmonary origin neoplasia and radiologist reports concluding thorax tumors, which had a lung dependency. But patients had a very low performance status, because they did not assist to the second appointment or never started treatment; finally they died by the disease. The prevalence of these tumors was slightly more common in men. 50% of the patients were between 60.7 and 74 years old. The median age was 69.1 years for males and 64.1 for women. This age median differences were statistically significant (F=9,121 p value=0,003). Also, 90.8% of the patients were from urban areas. 85.3% of tumors treated during 2014 corresponded to NSCLC, meanwhile 10% were Small Cell lung cancer. It was also observed a relationship of 1.7 patients with Squamous cellular carcinoma for every patient with Adenocarcinoma. 28 patients were tested for the EGFR mutation analysis, from these, 5 were mutated. Squamous cellular carcinoma patients were older than Adenocarcinoma patients. Besides this, patients with Small cell had a Media and Median age higher than the squamous cellular carcinoma. Although, Squamous cellular tumor patients were more frequent, the median survival time was inferior to adenocarcinoma patients and the Non-Small cell lung cancer. And neuroendocrine tumor patients had also a longer survival than Squamous cellular patients.
Conclusion:
Pathological characteristics of Lung cancer patients in Colombian Coffee Zone are in general similar than the other latitudes, predominating the squamous cellular carcinoma and with an incidence around 10% of the small cell carcinoma; it is striking the sex relationship close than 1:1, presumably for the early incorporation of the female population to smoking habit and to others known risk factors like the expose to combustion biomass smoke. The epidermic growth factor receptor (EGFR) mutation was observed in same proportion than in other studies.
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P2.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 207)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/08/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P2.01-031 - Characteristics of Squamous Cellular Carcinoma Patients In 'Colombian Coffee Zone' (ID 3137)
09:30 - 09:30 | Author(s): J.W. Martinez
- Abstract
Background:
During 1998 and 2013 the “Colombian Coffee Zone” (conformed by Caldas, Quindio, and Risaralda states) had an increase of 105 mortality cases of Bronchi and lung malignant tumors, as reported in death certificates.
Methods:
This is an observational and descriptive study that was made in patients at Clinica Oncologos del Occidente in the year 2014 and the Information was taken from the Clinical History Administration System (SAHICO). Thereafter, pending data was collected, by phone calls to patients or patient’s family, according to every case. Patients were interviewed to know their actual performance status and, in case of death, date and basic cause of death was asked.
Results:
SAHICO reported 178 patients with lung cancer. From these patients, 33 did not have a correct diagnosis. Basically they did not have histology report. There were 130 patients with Non-Small Cell Lung Cancer and Small Cell Lung Cancer. The frequency of lung cancer was slightly more common in men; most of the patients were from Risaralda, followed by Caldas. 50% of the patients were 60.7 to 74 years old. The median age for men was 69.1 years old, and 64.1 years old for women. These median ages differences were statistically significant (F=9,121 p value=0,003). And 90.8% of the patients were from urban areas. 85.3% of tumors treated in 2014 correspond to NSCLC, meanwhile 10% were Small Cell lung cancer. Patients who received radiation therapy had a longer survival than patients without any radiations treatment. The survival media in the radiotherapy group was 180.4 days, and 113.2 days for the group without radiation therapy. This difference was significant (Log Rank test: 4.74, p value 0.029). Only 2 patients had both surgery and radiotherapy and had the major survival time, with a media of 331 days. The mean age of the squamous cellular carcinoma patients was 69.8 years old in 64 patients. It was reported a median survival of 120 days with a confidence interval between 78 and 162 days. Only 8 patients with squamous cellular carcinoma had surgery and reported an increase in their survival time. The time median of survival for the surgical patients was 270 days. Meanwhile, this indicator decreased in the non-surgical patients to 109.9 days.
Conclusion:
In general, characteristics of lung squamous cellular carcinoma patients in the Coffee area of Colombia are similar than other regions of the world; incidence in men is only slightly greater than in women, presumably by the early age to start of smoke of the female population and the expose since childhood to others risk factors like biomass combustion smoke. Is clear that patients are detected in an advance stage of disease which has strong influence in prognosis and outcome. Highlights the importance of an integral treatment including all management alternatives and a multidisciplinary equipment of attention for modification of prognosis and survival.
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P3.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 208)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.01-027 - Lung Adenocarcinoma in Patients from the Colombian Coffee Zone (ID 3087)
09:30 - 09:30 | Author(s): J.W. Martinez
- Abstract
Background:
During 1998 and 2013 the “Colombian Coffee Zone” (conformed by Caldas, Quindio, and Risaralda states) had an increase of 105 mortality cases of Bronchi and lung malignant tumors, as reported in death certificates.
Methods:
This is an observational and descriptive study that was made in patients at Clinica Oncologos del Occidente in the year 2014 and the Information was taken from the Clinical History Administration System (SAHICO). Thereafter, pending data was collected, by phone calls to patients or patient’s family, according to every case. Patients were interviewed to know their actual performance status and, in case of death, date and basic cause of death was asked.
Results:
SAHICO reported 178 patients with lung cancer. From these patients, 33 did not have a correct diagnosis. Basically, they did not have a histology report. This happens in patients that consulted with a clinical presentation compatible with a pulmonary origin neoplasia and radiology reports concluding in thorax tumors, which had a lung dependency. But such patients had a very low performance status, because they did not assist to the second consult, they never started treatment, and finally because they died. Among these 178 patients 3 had other diagnoses, which initially were unclear: one had Gastric Cancer, the second had prostate carcinoma and the last one had breast cancer. Also, 12 Patients came with the diagnosis of Adenocarcinoma or Squamous cellular lung cancer, they only went to radiation treatment with us and the rest of the clinical treatment was taken in another clinic, or they died before treatment initiates, this group was called without following. There were 38 patients with adenocarcinoma. The proportion between Squamous Cellular and Adenocarcinoma was 1.7 patients with squamous cellular carcinoma for every patient with Adenocarcinoma. 28 patients were tested for the EGFR mutation analysis, from these, 5 had the EGFR mutation. The average age of the patients with adenocarcinoma was 64.2 years old. The median survival time found was 167.6 days and the calculation for confidence interval of 95% (CI~95%~ 67.3 to 267.9)
Conclusion:
Of the population evaluated, proportion of lung adenocarcinoma (ratio of tumors), is different than other reports of the world. Outcome is like patients with another tumors, because they consult to late, in advance stage of disease, then mortality is higher and shorter survival. Implementation in diagnosis of detection of epidermic growth factor receptor mutation (EGFR) in the institution has been of great value to reorient pharmacological treatment.
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P3.05 - Poster Session/ Prevention and Tobacco Control (ID 217)
- Event: WCLC 2015
- Type: Poster
- Track: Prevention and Tobacco Control
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.05-009 - Tobacco Consumption in Cancer Patients from Colombia's Coffee Zone (ID 3157)
09:30 - 09:30 | Author(s): J.W. Martinez
- Abstract
Background:
The General Surgeon has been reporting the similarities of the addiction magnitude of nicotine, heroin and cocaine. The criteria for diagnosis of dependency to nicotine have been established by the DSM-IV which includes impulsivity for consumption, lack of control despite the negative effects of smoking, and a high motivation to consume above other activities that can be done instead. Other elements of diagnosis are signs of physical dependency and tolerance which demands an increase in consumption. The effects of nicotine have been related to the fact that inhalation of nicotine by a large body surface such as the lungs, which is dissolved at a high pH fluid, which is transported from the lungs to the heart and quickly reaches the brain. The high rate of absorption and large amount of nicotine is concentrated in the brain are the two causes that generate dependency. Smoking also affects the processes of tissue repair and states that the mortality among current smokers is 2 to 3 times as high as that among persons who never smoked. We evaluate cigarette smoking in cancer patients “Colombia’s Coffee Zone”
Methods:
Oncologos del Occidente has clinics for the attention of cancer patients throughout “Colombia’s Coffee Zone” conformed by Caldas, Quindio and Risaralda states. Inhabited by 4.8% of the national population and during 2004, 4340 cancer patients had their first medical appointment. We measured cigarette consumption with surveys and validated tests and the level of dependency to tobacco of these new patients through a systematic sampling
Results:
The prevalence of cigarette consumption through life was 44.6% (IC~95% ~37.0-52.5) in 168 tested patients; former smokers consumed an average of 0.7 cigarette packs per year during 21.6 years. Current smokers consume an average of 0.67 cigarette packs per year during 42 years. The 61% of these patients wait until 30 minutes to consume their first cigarette of day, after they get up from bed. The 38% of the current smokers do not like to avoid the first cigarette of the day. The 50% smokes even when they fill ill and stay in bed, meanwhile the 16.7% of the patients want to smoke “right now”; the 22.2% feel less depressed and tired when they smoke.
Conclusion:
There is a high frequency of consumption among these cancer patients who also present high levels of dependence; this is why they require support to quit smoking tobacco. The pharmacological effects of nicotine must be medically evaluated. We propose a clinic to support these patients in the cessation of tobacco consumption.
