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Y. Yu
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P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Advanced Diseases - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.01-023 - Discrepancy of ALK Status in Lung Adenocarcinoma Subtypes According to the IALSC/ATS/ERS Classification in Chinese Patients (ID 2213)
09:30 - 09:30 | Author(s): Y. Yu
- Abstract
Background:
This study aimed to determine the relationship between ALK status and predominant subtype, according to the IALSC/ATS/ERS classification.
Methods:
A reclassification of 638 surgically resected adenocarcinomas was performed in Shanghai Chest Hospital. ALK Status was detected by immunohistochemistry (Ventana Medical Systems) in these patients.All of the cases were confirmed by two independent pathologists.
Results:
The most prevalent subtype was acinar predominant (46.0%), followed by papillary predominant (25.2%), solid predominant (9.2%), micropapillary predominant (8.7%), variants of invasive adenocarcinoma (5.5%), lepidic predominant(5.3%), minimally invasive adenocarcinoma(2.0%), and adenocarcinoma in situ(1.0%). ALK positive was identified in 29 of 638 tumors (4.5%). The ALK positive frequencies were: 3.0%(8/284) for acinar predominant, 1.9%(3/156) for papillary predominant, 12.3%(7/57) for solid predominant, 5.3%(3/54) for micropapillary predominant, 17.6%(6/34) for variants of invasive adenocarcinoma, 3.0%(1/33) for lepidic predominant, 7.7%(1/13) for minimally invasive adenocarcinoma, and 0%(0/7) for adenocarcinoma in situ, respectively. ALK positive was significantly associated with the solid predominant subtype(p=0.003) and variants of invasive adenocarcinoma(p=0.0002).
Conclusion:
The ALK positive frequencies of solid predominant subtype and variants of invasive adenocarcinoma were higher than other subtypes.
