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  P3.24 - Poster Session 3 - Supportive Care (ID 160)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12905

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    P3.24-053 - Cause of death in early stage Non-small cell lung cancer treated with curative intent (ID 3464)

    09:30 - 09:30  |  Author(s): G. Bannick
    • Abstract

    Background
    Lung cancer is the main cause of cancer death in men and women in Australia. Cure can be achieved by identifying patients with early (i.e. stage I and II) disease, treating them with surgery or radical radiotherapy. Despite this, the 5 year survival for stage I and II patients is reported at 60%. We looked at the cause of death in patients treated with curative intent over a 2 year period.

    Methods
    Local clinical practice information was collected in a prospective database. Cases presented at a multidisciplinary lung cancer meeting over a 24 month period (April 2006 -March 2008) were analysed. Patients with early stage NSCLC (stage I and stage II) based on the 6[th] edition IASLC TNM classification were identified (n=62). Treatment data was obtained for all identified cases (n=62/62) via hospital records. Cause of Death was determined via the death certificate as submitted to the Registry of Births, Deaths and Marriages.

    Results
    Five year survival was 25% (16/62) for early stage NSCLC. Cause of death of obtained for all but 3 patients (43/46). 74% (46/62) of patients received treatment with curative intent, 37% (23/62) surgery and 20% (13/62) radical radiotherapy. Of all patients who underwent radical treatment, lung cancer was the primary cause of death in 16% (10/46). Respiratory conditions were the second most common cause of death with 13% (6/46) attributed. The main cause was reported as pneumonia in 7 patients, COPD, IPF and Respiratory failure being others. The loss of lung from surgery or radiotherapy could be hypothesised to be a factor in these deaths due to reduce lung volume. Cardiac disease was the cause of death in 5 patients and 3 patients died due to bladder cancer, both diseases strongly associated with smoking. 1 patient died due to colonic cancer and 1 due to vascular dementia. Patients who underwent surgical resection had lower mortality rates than those who underwent radiotherapy with a 5 year survival in the surgical cohort of 60% (14/23) vs 7% (1/13) in the radical radiotherapy cohort as well as lower rates of lung cancer related death 17% (4/23) vs 46% (6/13).

    Conclusion
    Mortality in early stage lung cancer remains high in our cohort with recurrence of the lung cancer being the main cause of death. All patients were staged with PETCT prior to treatment. Diseases strongly associated with smoking were a common cause of disease as may be expected. Patients with radical therapy presenting with pneumonia are at high risk of death.