Author of

• 12853

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  P3.24 - Poster Session 3 - Supportive Care (ID 160)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12869

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    P3.24-016 - A case of primary myoepithelial carcinoma of the lung (ID 1156)

    09:30 - 09:30  |  Author(s): T. Ii
    • Abstract

    Background
    Myoepithelial tumors commonly occur in the salivary glands, the sweat glands or the mammary glands, but extremely rare in the lung. We present a case of primary myoepithelial carcinoma of the lung with reports of previous cases.

    Methods
    A 67-year-old man presented with a nodular lesion in the lower lobe of the left lung. The patient had a surgical history of stenosis of the small intestine, and his serum carcinoembryonic antigen (CEA) level was slightly elevated. Histopathological examination revealed that the cause of intestinal stenosis was the ischemic enteritis. Computed tomography (CT) was carried out as screening for elevated CEA, and a small nodule was detected at the posterior basal segment (S[10]) of the left lung. The pulmonary nodule developed a tendency to increase during progress observation of half a year. Because of the clinical suspicion of malignancy, he underwent a wedge resection of the left lower lobe by video-assisted thoracic surgery (VATS).

    Results
    Macroscopically, the tumor was a whitish, well-circumscribed, irregular shaped, and solid mass measuring 10×8×6 mm in size. Microscopically, the tumor was mainly located outside the bronchial mucosa with focal invasion into the lamina propria of the mucosa, and composed of atypical cells arranged in trabecular or alveolar pattern and basement membrane-like eosinophilic hyaline stroma. The tumor cells had ovoid pleomorphic nuclei varying in size and clear cytoplasm. Small necrotic foci were scattered in the tumor. Mitotic figures were frequently seen (> 14/10 HPF) and abnormal mitoses were occasionally encountered. No ductal structures were found throughout the tumor. Immunohistochemical staining showed the tumor cells were positive for 34βE12, P-63, S-100, α-SMA, but negative for CK7, TTF-1, chromogranin A, synaptophysin, CD56. On the basis of the above features, the tumor was diagnosed as primary myoepithelial carcinoma of the lung (pT1aN0M0, Stage IA). The patient is doing well without recurrence for 22 months after the operation.

    Conclusion
    We present a rare case of primary myoepithelial carcinoma of the lung. To our knowledge, only nine cases of pulmonary myoepithelial carcinoma have been reported in the literature so far. Because the clinical course of those cases was poor, further studies will be necessary in order to clarify their histological features, biological behavior, effects of chemotherapy or radiotherapy, and clinical outcome.