Author of

• 12791

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  P3.19 - Poster Session 3 - Imaging (ID 181)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12799

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    P3.19-008 - Positron Emission Tomography Scan in Lung Cancer: New Insights In Tumor Biology? (ID 1678)

    09:30 - 09:30  |  Author(s): V. Sacramento
    • Abstract

    Background
    [18]F-fluoro-2-deoxy-glucose (FDG) uptake on Positron Emission Tomography (PET) is highly accurate in the detection of mediastinal lymph node metastasis and extrathoracic metastasis and plays an important role in the staging of lung cancer. Furthermore, recent studies suggest that PET-CT and Standardized Uptake Value (SUVmax) reflects tumor metabolism and proliferation capacity, and can be used as a prognostic factor as well as to predict response to therapy.

    Methods
    Our study aims to detect SUVmax differences between different lung cancer histologic sub-types. We conducted a retrospective single centre study. All lung cancers diagnosed in 2008-2009, with a PET-TC evaluation at diagnosis, and with follow-up at IPOLFG were included. Data regarding socio-demographic factors, smoking habits, histological diagnosis, staging, and performance status were obtained from clinical chart reviews. Statistical analysis was performed using STATA

    Results
    A total of 92 patients have been included in this study to date. 64 (69.6%) of our patients were male and 28 (30.4%) were female. Median age was 64.5 years, standard-deviation of 10.16 years, minimum of 36 and maximum of 82 years. 47 patients (51.65%) were current smokers, 31 (34.07%) were former smokers, and 11 (12.09%) were non-smokers. 54% presented ³ 40 Pack years. The most frequent histologic sub-type was Adenocarcinoma (ADC) (41.3%), followed by Squamous Cell Carcinoma (SCC) (30.4%). 42 patients had stage I or II lung cancer, 31 had stage III, and 19 with stage IV. The median size of the primary tumor lesion was 4.05cm (standard-deviation of 2.62cm), and the median SUVmax was 10.11 (standard deviation of 5.86). SUVmax by primary tumor histological sub-type revealed the following characteristics: median SUVmax in the SCC group was 12.12 (standard-deviation 6.3), ADC group 8.26 (standard-deviation 4.5), Non-small Cell Carcinoma group 12.65 (standard-deviation 7.5), Neuro-endocrine Carcinoma group 7.25 (standard-deviation 5.4) and Small Cell Carcinoma 10.67 (standard-deviation 3.6). The observed differences were statistically significant between the 5 considered groups (p=0.0233, One-way ANOVA) and specifically, we observed a highly significant difference in SUVmax between SCC and ADC groups (p=0.005, t-test). We also observed a positive correlation between tumor size and SUVmax.

    Conclusion
    Our preliminary results confirm the effect of tumor biology in PET-CT and SUVmax with observed differences between different histological sub-types, and suggest that PET-CT can be specifically important in the assessment of SCC and ADC subtypes. These results support further studies regarding the usefulness of PET-CT in tumor biology characterization in SCC and ADC subgroups.