Author of

• 12769

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  P3.18 - Poster Session 3 - Pathology (ID 177)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12780

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    P3.18-011 - Prognostic value of blood and lymphatic vessels embolism (pV, pL) in early stage lung cancer (IA, IB). (ID 2309)

    09:30 - 09:30  |  Author(s): W. Kupis
    • Abstract

    Background
    Stage of lung cancer (TNM) is most valuable prognostic factor. Most of patient in IA and IB stage survive 5 years, but in 10% of them the relapse of the disease is noticed. Therefore identifying the negative prognostic factors is crucial. The neoplastic emboli in blood and lymphatic vessels seem to be one of them.

    Methods
    The retrospective analysis of lung cancer patients operated on from 2002 thru 2006 at our institution was done. In all patient included into the study group the IA or IB stage was diagnosed and the neoplastic emboli in both blood and lymphatic vessels of the tumor were found. The survival rate in this group was compared with those without such findings. Among 1648 patient operated on between 2002 and 2006 564 were classified as IA or IB (pN0) stage (after rejecting 22 of them due to R1). Among 271 pts during microscopic detection neoplastic emboli in blood or lymphatic vessels were found. The analyzed group consisted of 208 women and 356 men. The stage IA was established in 212 pts, including 115 in pT1a, 97 in pT1b. Stage IB was diagnosed in 352 pts (pT2a) among whom 149 have infiltration of parenchymal pleura detected. All of them underwent the radical resection – all surgical margins were negative. The pathological examination revealed adenocarcinoma in 230 pts, squamous cell lung cancer in 203 pts, large cell lung cancer in 30, carcinoid in 80 pts and other kind of NSCLC in remaining 21 pts.

    Results
    5-year survival rates recorded were as follow – in stage IA 79,9% and 74,1% in pT1A pT1b respectively, in stage IB (pT2a) 59,9%. The presence of neoplastic emboli in blood and lymphatic vessels of tumor correlated with poorer prognosis of survival (V=0 L=0 – 72%, V=1 L=0 63,3%, V=0 L=1 64,7%, V=1 L=1 58,1%).

    Conclusion
    Therefore we concluded that such finding should be considered a negative prognostic factor and ought to be recorded in every pathology report.