Author of

• 12769

  +

  P3.18 - Poster Session 3 - Pathology (ID 177)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Pathology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12770

    +

    P3.18-001 - Prognostic value of the IASLC/ATS/ERS classification in stage I lung adenocarcinoma patients (ID 348)

    09:30 - 09:30  |  Author(s): Z. Song
    • Abstract

    Background
    A new lung adenocarcinoma classification proposed by the International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) has recently been published in 2011.We investigated the relationship between predominant subtype, according to the (IASLC/ATS/ERS) lung adenocarcinoma classification and prognosis in stage I lung adenocarcinoma in our hospital.

    Methods
    Two hundred and sixty-one patients with stage I lung adenocarcinoma operated in Zhejiang Cancer Hospital were identified between 2000 and 2010. Survival curves were plotted using the Kaplan–Meier method. The Cox proportional hazard model was used for multivariate analysis.

    Results
    The median age of the 261 patients was 59.8 years in current cohort. Of the 261 patients, 175 patients (67.1%) were never smokers, 86 patients (32.9%) were former or current smokers. The surgical procedure employed 245 lobec­tomy, 12 bilobectomy and 4 pneumonectomy. The pathologic stage was IA in 92 patients (35.2%), IB in 169 patients (64.8%).No cases were adenocarcinoma in situ and six were minimally invasive adenocarcinoma. Two hundred and fifty-five cases were invasive adenocarcinoma, in which 80 were papillary predominant, 76 were acinar predominant, 42 were micropapillary predominant, 34 were solid predominant, 19 were lepidic predominant subtypes, and 4 were variants of invasive adenocarcinoma. The 5-year DFS and OS rates for the all patients were 66.0%, 78.2%, respectively. Micropapillary predominant subtype (p=0.037), solid predominant subtype (p=0.035) were predictive of DFS. Patients with micropapillary and solid predominant tumors had significantly worse disease-free survival compared with other subtypes predominant tumors ( p＜0.001).Multivariate analysis revealed that the new classification was an independent predictor of disease-free survival and overall survival (p=0.002 and 0.015).

    Conclusion
    The predominant subtype in the primary tumor was associated with prognosis in resected stage stage I lung adenocarcinoma.