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S.H. Lee



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    P3.13 - Poster Session 3 - SCLC (ID 202)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Medical Oncology
    • Presentations: 1
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      P3.13-004 - A multicenter phase II study of belotecan, a new camptothecin analogue, in elderly patients with previously untreated, extensive-stage small cell lung cancer (ID 1335)

      09:30 - 09:30  |  Author(s): S.H. Lee

      • Abstract

      Background
      Belotecan is a new camptothecin analogue and a potent topoisomerase I inhibitor. The aim of this phase II study was to investigate the efficacy and toxicity of belotecan in previously untreated elderly patients with small cell lung cancer (SCLC).

      Methods
      A total of 26 patients, aged ≥65 years, with previously untreated, extensive-stage SCLC were enrolled in the study. Belotecan was administered by daily intravenous infusion at 0.5 mg/m[2]/day for 5 consecutive days every three weeks.

      Results
      The overall response rate and disease control rate of chemotherapy on an intention-to-treat basis were 35% and 54%, respectively. The median overall survival was 6.4 months, and the median time to progression was 2.8 months. The most common toxicity was hematologic. Grade 3 or 4 neutropenia occurred in 80.8% of patients, and grade 3 or 4 thrombocytopenia in 15.3%. Non-hematologic toxic effects of grade 3 or 4 were uncommon.

      Conclusion
      Belotecan had modest efficacy and well-tolerated toxicity in previously untreated, elderly SCLC patients. Single belotecan could be a promising treatment option, considering its lower toxicity in elderly patients who are unsuitable candidates for platinum plus etoposide chemotherapy.

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    P3.17 - Poster Session 3 - Bronchoscopy, Endoscopy (ID 185)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track:
    • Presentations: 1
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      P3.17-005 - Diagnostic Yield of Flexible Bronchoscopy in Evaluating Peripheral Lung Lesions Without Endobronchial Lesions (ID 2131)

      09:30 - 09:30  |  Author(s): S.H. Lee

      • Abstract

      Background
      The diagnosis of peripheral lung lesions (PPLs) continues to be a commom problem in routine clinical practice. Despite bronchoscopy with guidance has evolved from fluoroscopy to endobronchial ultrasonography and electromagnetic navigation recently, conventional flexible bronchoscopy without guidance is still the most widely used because it is more readily available and inexpensive. The aim of this study was to evaluate the diagnostic yield and factors affecting diagnostic yield of flexible bronchoscopy without guidance for peripheral lung lesions.

      Methods
      We retrospectively reviewed the medical records of all the patients who underwent flexible bronchoscopy at St. Paul’s hospital of the Catholic University of Korea between Jan 2007 and Mar 2013. Two hundred four patients had lung lesions without endobronchial lesion. Among these, 24 patients were excluded due to follow-up loss and additional 11 patients were excluded because the lesions were deemed inactive in clinical follow up.

      Results
      One hundred sixty-eight patients were enrolled in this study. The overall diagnostic rate was 58.3%. Sensitivity was 43.2% in malignant disease and 78.1% in benign disease. Non-diagnostic results of bronchoscopy were compared with subsequent PCNA or surgical resection. Nodule location and the distance from the pleura did not effect on the diagnostic yield of bronchoscopy. The bronchus sign on CT imaging was present in 45.7% of the patients. The diagnostic yield was significantly higher for lesions with bronchus sign (81.2%) than for lesions not having bronchus sign (39.0%; P<0.001). The diagnostic yield of bronchoscopy increased according to different ranges of lesion diameter; 10 mm or smaller, 11-20 mm, 21-30 mm, 31-40 mm, 41-50 mm, and greater than 50mm were 16.7%, 32.0%, 50.0%, 57.1%, and 58.8% respectively (linear P<0.001). The diagnostic yield was significantly higher for lesions >3 cm (67.5%) than for lesions <3cm (47.9%; P < 0.02).

      Conclusion
      This study suggests that the presence of bronchus sign and larger (>30 mm) nodule are useful findings to predict outcome of conventional bronchoscopy without guidance.