Author of

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  P3.11 - Poster Session 3 - NSCLC Novel Therapies (ID 211)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

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    P3.11-038 - EGFR mutations in squamous NSCLC - prevalence and treatment results with EGFR tyrosine kinase inhibitors in Slovak Republic (ID 2731)

    09:30 - 09:30  |  Author(s): K. Zavodna
    • Abstract

    Background
    Wide screening for EGFR mutations in locally advanced or metastatic squamous NSCLC (SQLC) is not recommended by internationally accepted guidelines, mainly due to low prevalence. However, the COSMIC database shows the increasing incidence of EGFR mutations in SQLC, in 2008: 2,6% (upper limit of 95%CI: less than 3,6%), in 2012: 5%, and in April 2013: 6% (upper limit of 95%CI: 6,9%). In spite of this, there are only very limited data about the efficacy of EGFR tyrosine kinase inhibitors (TKIs) in patients with SQLC containing activating EGFR mutations. The Purpose of this study was to assess the prevalence of EGFR mutations in SQLC in the Slovak Republic, and to assess the treatment results with TKIs in this group of patients.

    Methods
    A nationwide multicentre retrospective study was designed, and approved by the Ethical Committee of the National Cancer Institute, Bratislava, Slovakia. The databases of the participating institutions were searched for patients with locally advanced or metastatic SQLC tested for EGFR mutations between March 2010 and March 2013. The time limit reflects the fact, that the EGFR mutation testing has been available for all patients with locally advanced or metastatic NSCLC in the Slovak Republic since March 2010.

    Results
    Altogether 1502 patients with NSCLC were tested for EGFR mutations, among them 585 with SQLC. EGFR mutations were found in 26 SQLC cases, which give the prevalence 4.4%, 95%CI: 3.1 – 6.4%. Thirteen patients received treatment with EGFR TKIs, 10 with gefitinib, 3 with erlotinib. Patients’ characteristics: M/F: 10/3, age: median 65yrs (55 – 83), PS: 1/2/3: 1/10/2, all with stage IV SQLC, cytologically and histologically confirmed in 11 (85%), cytologically only in 2 (15%) patients. Treatment results: RR: PR: 7/11 (64%), SD: 2/11 (18%), PD: 2/11(18%), UNK: 2/13, PFS: median: 5.5 months (1 – 36+). PFS over 12 months was seen in 3 patients. There were no unexpected or treatment related SAEs.

    Conclusion
    EGFR mutations in SQLC as well as the treatment efficacy of EGFR TKIs in patients with SQLC containing EGFR mutations deserve further attention. EGFR mutation testing should be available also for patients with SQLC.