Author of

• 12592

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  P3.10 - Poster Session 3 - Chemotherapy (ID 210)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12638

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    P3.10-046 - Patients with advanced non-small cell lung cancer(NSCLC) received multi-line treatments had better efficacy (ID 2804)

    09:30 - 09:30  |  Author(s): X. Zhang
    • Abstract

    Background
    Efficacy of advanced non-small cell lung cancer treatment has been in platform. How to integrate the limited drugs and design the sequence of regimens is the key point in clinical practice.

    Methods
    Clinical data of 215 patients of pathologically confirmed advanced non-small cell lung cell from January 2010 to December 2012 was analyzed retrospectively. The clinical features, pathological diagnosis, numbers of treatment lines and the efficacy were analyzed. Efficacy and adverse events were evaluated according to the RECIST 1.1 Criteria, NCI Common Terminology Criteria v3.0, respectively.

    Results
    Among 215 patients treated in our cancer center, 135 were men and 84 were women. The squamous cell carcinoma and adenocarcinoma was 50 and 74 in man ; 8 and 70 in women, respectively. 111 cases had 1 line treatment, 53 had 2 lines, 31 had 3 lines, 10 had 4 lines and 9 had more than 4 lines. In all lines, patients with adenocarcinoma compared to the squamous cell carcinoma had more opportunities to receive more drugs(P<0.05). The therapy regimen was decided by the Chinese medical insurance. Combined with platinum, gemcitabine was 29.3% and Taxanes was 26.5%. Either of these two regimens was the preferred choice. Tyrosine kinase inhibitors(TKI) including those offered by clinical trail and pemetrexed which were paid at patients’ own expense were 14%, 22.8%, respectively. In patients received 1, 2 and multi-line therapy(more than 2 lines), the partial response rate was 14.4%, 3.8%, 0, respectively. The stable disease rate was 28.8%, 32.1%, 30%, respectively. OS of patients with multi-line therapy(more than 2 lines) was longer than those with 1 and 2 lines treatment but the data was not mature.

    Conclusion
    Patients with advanced non-small cell lung cancer had multi-line treatment had better disease control. Their regimens mainly covered the chemotherapy and TKIs. Limited of the Chinese medical insurance, the first choice was gemcitabine/taxanes combined with platinum. Tailored therapy may explore the rational therapy sequence to get much better efficacy.