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H. Ban



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    P3.10 - Poster Session 3 - Chemotherapy (ID 210)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Medical Oncology
    • Presentations: 1
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      P3.10-014 - Efficacy and Safety of docetaxel plus oxaliplatin as a first-line chemotherapy in patients with advanced or metastatic Non-small-cell Lung Cancer (ID 1285)

      09:30 - 09:30  |  Author(s): H. Ban

      • Abstract

      Background
      Platinum doublets are standard first-line treatment of stage IV non-small-cell lung cancer (NSCLC) without targetable driver mutations such as EGFR or ALK. Oxaliplatin is known to be more potent than cisplatin, requiring fewer DNA adducts to provide equivalent cytotoxicity. The objective of this study is to evaluate the efficacy and safety of oxaliplatin combined with docetaxel as a first line treatment of stage IV NSCLC.

      Methods
      This is prospective, single-center, phase II trial. Patients with chemotherapy-naive NSCLC received docetaxel 60mg/㎡ (day 1) and oxaliplatin 70mg/㎡ (day 2) every 3 weeks for up to 6 cycles. The primary endpoint was objective response rate (ORR) and the secondary endpoints were progression-free survival (PFS), overall survival (OS) and safety. Treatment response was evaluated according to RECIST version 1.1.

      Results
      Thirty three patients were enrolled and response evaluation is available in 30 patients at the present time. There were 10 partial responses, 16 stable diseases. ORR was 33.3% and disease control rate was 86.7%. Median PFS was 127 days (95% confidence interval, 59~195) and median OS was 394 days (95% confidence interval, 264~524). Grade 3-4 toxicities occurred in 45% of patients, and the most common hematologic toxicity was neutropenia. There were two cases of hyperglycemia and sepsis.

      Conclusion
      This study suggests that the combination of oxaliplatin and docetaxel is effective in patients with NSCLC, with reasonable toxicities. (ClinicalTrials.gov Identifier: NCT01243775)