Author of

• 12573

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  P3.09 - Poster Session 3 - Combined Modality (ID 214)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Combined Modality
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12585

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    P3.09-012 - A decade of community-based outcomes of patients treated with curative radiotherapy (RT) +/- chemotherapy for Non-Small Cell Lung Cancer (NSCLC). (ID 2046)

    09:30 - 09:30  |  Author(s): A. Pramana
    • Abstract

    Background
    There are many clinical trials reporting good outcomes of patients treated with curative RT. However, clinical trials populations are highly selected and there are limited data on whether these outcomes are seen in community practice in the Australian setting. The aim of the study was to evaluate the outcomes and toxicity of patients treated with curative RT +/- chemotherapy for NSCLC.

    Methods
    Electronic medical records at Liverpool and Macarthur Cancer Therapy Centres, NSW, Australia were queried to retrieve data on patients with Stage I-III NSCLC who were treated with curative RT (minimum dose 60Gy) between 1/1/2000-31/12/2010. Patient death records were available up until 16/1/2013 with a minimum follow up time for patients of 2 years. Patient demographic data, tumour, and treatment details were retrieved. The records were retrospectively reviewed to collect data on patient comorbidities and treatment toxicities. The Simplified Comorbidities Score (SCS) was used to score comorbidity. The median follow up time was 22 months. For Cancer Specific Survival (CSS), patients were censored if they had died from another cause or survived until the last date of follow up, and for Overall Survival (OS), patients were censored if they survived until the end of the study. Univariate and multivariate Cox proportional hazards models were used to assess predictors of CSS and OS.

    Results
    One hundred and sixty patients were treated with curative RT over this period. The median age was 69 years (range 36-89). Seventy-six patients received RT alone, 59 received concurrent chemo-radiation, and 25 received sequential chemo-radiation. Twenty-nine patients had stage I disease, 28 had stage II, and 103 had stage III. Median overall survival was 29 months for patients with stage I NSCLC, 26 months for stage II, and 18 months for stage III. For stage II and III patients treated with concurrent chemo-radiation, median survivals were 29 and 18 months and 2-year OS were 64 and 42% respectively. On multivariate analysis, stage II or III and weight loss ≥5% were predictive of cancer specific survival with hazard ratio 4.47 (95% CI: 10.8-18.55, p=0.039) and 2.23 (95% CI: 1.13-4.39, p=0.021). Toxicity was acceptable with 2% grade ≥3 radiation pneumonitis, 6% grade ≥3 oesophagitis, and 2% grade ≥3 febrile neutropenia. There was no treatment-related death. Performance status, age, SCS, respiratory function, pathology, and grade were not predictive of survival.

    Conclusion
    Curative intent RT +/- chemotherapy is well tolerated and effective treatment for inoperable or locally advanced NSCLC. Tumour outcomes and toxicities were comparable to those reported in clinical trials. Higher SCS was not correlated with worse survival in this cohort.