Author of

• 12441

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  P3.06 - Poster Session 3 - Prognostic and Predictive Biomarkers (ID 178)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Biology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/30/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 12487

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    P3.06-047 - Prognostic value of neutrophil lymphocyte ratio in second line advanced malignant pleural mesothelioma (ID 3135)

    09:30 - 09:30  |  Author(s): M. Yahia
    • Abstract

    Background
    Malignant pleural mesothelioma is a lethal disease and hence the strong need for identifying new prognostic factors.

    Methods
    This is a retrospective study including all eligible patients with advanced malignant pleural mesothelioma (MPM) presenting to National Cancer Institute, Cairo University. Neutrophil lymphocyte (N/L) ratio was assessed before second line chemotherapy.2.5 was used as the cutoff point. Endpoints were assessment of correlation between N/L ratio and clinical response (CR), progression free survival (PFS) and overall survival (OS).

    Results
    52 patients (19 stage III and 33 stage IV) MPM were included and followed up during the period from July 2009 till November 2012 with a median follow up period of 2.6 months. 87.5% of patients with N/L ratio > 2.5 showed progressive disease versus 91.7% in patients with N/L ratio <2.5. (P-value=0.66).6 months PFS was 11% for patients with N/L ratio > 2.5 versus 14% for patients with N/L ratio <2.5. (P-value =0.001). 6 months OS was 72% for patients with N/L ratio > 2.5 versus 66% for patients with N/L ratio <2.5. (P-value =0.4).

    Conclusion
    N/L ratio is a potential prognostic marker for advanced MPM treated with second line chemotherapy.