Author of

• 11946

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  P2.24 - Poster Session 2 - Supportive Care (ID 157)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11976

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    P2.24-030 - Increasing Therapeutic Efficacy and Safety of Docetaxel in Lung Cancer (ID 2067)

    09:30 - 09:30  |  Author(s): N. Bascomb
    • Abstract

    Background
    Docetaxel is an accepted second line drug for NSCLC not used frequently for its side effects. VT-122 (propranolol and etodolac) which has anti-angiogenic COX-2 inhibition properties. Modifying the tumor-microenvironment and sympathetic system has anticancer activity as well as ameliorates toxicity of anticancer drugs. Docetaxel efficiency can be improved with VT-122 which possesses the above property. To increase efficacy of docetaxel and safety profile using VT-122.

    Methods
    20 (10 in each arm) patients (55-65 years) were treated with docetaxel (75mg/m[2]) with or without VT-122. VT-122 was started 7 days before giving docetaxel. Propranolol doses were titrated to maintaining heart rate around 60. Etodolac was titrated on the basis of CRP to a maximum of 1200mg.

    Results
    Overall Response seen in 4 patients (VT-122 arm) and 2 patients (docetaxel arm). 6 patients in VT-122 arm completed 6 cycles of docetaxel while in non-VT-122 4 patients completed the 6 cycles. 1 year survival was 30% vs 10%; p=0.025. Grade III/IV hematologic toxicity was decreased by 50% ie 6 cases in docetaxel arm and 3 in VT-122. In non-hematological toxicity this trend was seen for asthenia, neuropathy, skin and nail changes and weight loss.

    Conclusion
    Addition of VT-122 (propranolol and etodolac) increases efficacy of docetaxel and is cost effective.