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T.D. Thanh



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    P2.22 - Poster Session 2 - Epidemiology, Etiology (ID 167)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Prevention & Epidemiology
    • Presentations: 1
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      P2.22-002 - Study of Some Factors Related to Epidemiology In Malignant Pleural Mesothelioma (ID 240)

      09:30 - 09:30  |  Author(s): T.D. Thanh

      • Abstract

      Background
      Malignant Pleural Mesothelioma (MPM) is a rare disease and often associated with a history of long-term exposure to asbestos. Recently, It’s related to Simian virus 40 (SV-40). The determination is related to exposure to asbestos based on clinical history and possible asbestos in tissue pathology specimens. Diagnosis related to SV-40 based on immunohistochemical staining The Simian Virus 40 Large T Antigen.

      Methods
      : Retrospective descriptive statistics. Survey by interviewing patients and pathological examine specimens can find asbestos and immunohistochemistry with The Simian Virus 40 Large T Antigen.

      Results
      From Jan, 2008 to Dec, 2012 at the Pham Ngoc Thach Hospital, we have take diagnosis of 60 cases of malignant pleural mesothelioma, including 29 men and 31 women, with histopathological classification: 28 cases of epitheliod MPM (46.7%), 11 cases with biphasic MPM (18.3%), 09 cases with sarcomatoid MPM (15%), 06 cases with Desmoplastic MPM (10%), 04 cases with Well-Differentiated Papillary Mesothelioma (6.7%) and 02 cases with Anaplastic MPM (3.3%).  Elements related to contact asbestos: 22cases (44.4%).  Confirm the diagnosis of asbestos in tissue specimens:12cases(20%).  Presence of The Simian Virus 40 Large T Antigen: 11 cases (18,3%).  Only one case (1,7%) with both two factors positive asbestos and SV-40.  And having 16 cases (26,7%) did not identify epidemiological factors.

      Conclusion
      Through the the study series cases of Malignant Pleural Mesothelioma, initially issued a warning about the causative factors in those tumors, including long-term exposure to asbestos and can be caused by infections with Simian virus 40.