Author of

• 11890

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  P2.19 - Poster Session 2 - Imaging (ID 180)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11904

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    P2.19-014 - whole-body diffusion-weighted mri for staging non-small cell lung cancer patients (ID 3154)

    09:30 - 09:30  |  Author(s): F.J. Haddad
    • Abstract

    Background
    Therapeutic decision and prognosis in non-small cell lung cancer (NSCLC) relies on accurate staging. Currently, Positron Emission Tomography/Computed Tomography (PET/CT) appears to have better efficacy, and is considered the gold standard method for staging lung cancer. Diffusion-weighted Magnetic Resonance Imaging (DWI) for the whole body has become feasible and provides images with good resolution. Some investigators have suggested that DWI could be used for assessment of primary tumor, lymph nodes and distant metastases in lung cancer. To date there are few data assessing DWI for staging of NSCLC. The purpose of this study is to compare the role of DWI and PET/CT for staging NSCLC patients.

    Methods
    This is a prospective study. Institutional review board approval and written informed consent was provided by all patients. From May 2011 to April 2012, thirty-two patients were included. Twenty (62.5%) were men, and the mean age was 62.4 years old. Non-small cell lung cancer (NSCLC) was proved at pathological examination. PET/CT and brain MRI was performed as a routine staging work up. DWI was studied as an alternative method for staging. Final stage in each patient was defined by pathological examination when available or through radiologic and clinical examinations/follow-up. Sensitivity, specificity, and accuracy were evaluated and were compared between both groups.

    Results
    Preliminary results demonstrate that WB MRI and PET/CT have satisfactory levels of sensitivity, specificity and accuracy, with no significant difference (p>0.05), as disclose in Table 1. Table 1 – Sensibility, specificity and accuracy of WB MRI and PET/CT.

    	WB MRI	PET/CT
    Sensibility	72.3%	73.5%
    Specificity	91.6%	94.5%
    Accuracy	86.8%	88.2%

    Conclusion
    PET/CT has shown to be an excellent tool for the clinical staging of lung cancer. DWI has been considered an alternative method for staging these patients. Advantages of whole-body DWI include absence of ionizing radiation exposure, excellent contrast resolution and information from different sequences allowing a better characterization of lesions, mainly brain and liver metastasis. Our preliminary results demonstrate no significant difference in accuracy between both methods for staging patients with NSCLC.