Author of

• 11842

  +

  P2.15 - Poster Session 2 - Thymoma (ID 191)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Thymoma & Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11843

    +

    P2.15-001 - Predictors of long-term survivals in patients with Masaoka stage III thymomas (ID 44)

    09:30 - 09:30  |  Author(s): J. Lv
    • Abstract

    Background
    To analyse long-term survival rates, reccurence rates and prognostic factors of patients with Masaoka stage Ⅲ thymomas.

    Methods
    A total of 111 patients with stage Ⅲ thymoma treated in our hospital between September 1965 and December 2010 were retrospectively analysed. Sixty-eight patients(61.3%) were with complete resection, while 23 patients(20.7%)with incomplete resection and 20 patients(18%)with pure biopsy(18 patients wih thoracic exploration surgery and 2 patients with CT-guidied fine needle puncture biopsy). Fifty-six patients with complete resection(50.5%)and 10 patients with incomplete resection(9%) had postoperative radiation. Twenty patients with pure biopsy received post or preoperative radiation or chemotherapy with or without surgery.

    Results
    The median follow-up time was 66 months(5-540). The total overall survival (OS) rates、disease free survival(DFS)rates and disease specific survival (DSS) rates at 5 and 10 year were 75.3%、60.8%、81.9% and 54.7%、41.3%、67.1%, respectively. Postoperative radiotherapy did not improve OS、DFS、DSS compared to surgery alone (p=0.316, p=0.729 and p=0.601). The OS at 5 and 10 year among the patients with complete resection、incomplete resection and pure biopsy were 88%、59%、56.7% and 69.3%、30.6%、47.3%, repectively (p=0.002). The DFS at 5 and 10 year among the patients with complete resection、incomplete resection and pure biopsy were 73.9%、40.1%、41.2% and51.5%、26.7%、30.9%, repectively (p=0.003). The DSS at 5 and 10 year were 93.9%、69.2%、59.7% and 78.9%、46.2%、59.7%, respectively (p=0.004). The total failure rate was 36% (40/111), including 30.6% locoregional recurrence and 9% distant metastasis (including multisite failure). Local recurrent rates in patients with postoperative radiotherapy was lower than patients with surgery alone (9.4% and 19.2%), but the result was not statistically significant (p=0.173). On multivariate analysis, resection completeness (p=0.000) and lung involvement (p=0.024) were independent prognostic factors for DFS, and resection completeness (p=0.002)、age (p=0.028) and myasthenia gravis (p=0.038) were independent prognostic factors for DSS.

    Conclusion
    Patients with completely resected Masaoka stage III thymoma had a better survival and lower recurrence rates than patients with tumor incompletely resected. The role of postoperative radiation needs further investigation. Resection completeness and lung involvement were prognostic factors for DFS, and resection completeness、age and myasthenia gravis were prognostic factors for DSS.