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H.J. Kim



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    P2.09 - Poster Session 2 - Combined Modality (ID 213)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Combined Modality
    • Presentations: 1
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      P2.09-015 - Role of postoperative radiotherapy after curative resection and adjuvant chemotherapy for patients with pathological stage N2 non-small cell lung cancer: A propensity score matching analysis (ID 2953)

      09:30 - 09:30  |  Author(s): H.J. Kim

      • Abstract

      Background
      To evaluate the role of postoperative radiotherapy (PORT) after curative resection and adjuvant chemotherapy for patients with pathological stage N2 non-small cell lung cancer (NSCLC).

      Methods
      We performed a retrospective review of 219 consecutive patients who underwent curative surgery followed by adjuvant chemotherapy between 2000 and 2011. Among 219 patients, 41 received PORT additionally. Propensity scores for PORT receipt were calculated for each patient and used for matching to patients without PORT. 118 patients in non-PORT group and 39 patients in PORT group were matched. Clinical and pathologic characteristics were well-balanced after matching. PORT was delivered using conventional technique (n=13) or three-dimensional conformal technique (n=26) with median dose of 54 Gy (range, 50-60). The median follow-up duration for matched patients was 47 months.

      Results
      During the follow-up, 58 patients (49.2%) experienced loco-regional failure in the non-PORT group and 12 patients (30.8%) in the PORT group. Distant metastasis occurred in 68 patients (57.6%) in non-PORT group and 22 patients (56.4%) in PORT group. PORT was associated with improved loco-regional control rate (LRC) (5yr LRC 67.0% vs. 48.4%, p = 0.047), but not disease-free survival (DFS) (5yr DFS 43.3% vs. 32.3%, p = 0.257). An exploratory subgroup analysis suggested a potential DFS benefit of PORT in patients with multiple stations of mediastinal lymph node metastasis (5yr DFS 42.8% vs. 16.6%, p = 0.023). Grade 3 radiation pneumonitis and esophagitis was seen in only one patient, respectively.

      Conclusion
      In pathological stage N2 NSCLC patients, more than half eventually developed distant metastasis despite adjuvant chemotherapy. PORT increased LRC in these propensity-matched patients, but did not DFS. However, patients with multiple stations of mediastinal lymph node metastasis appear to benefit from PORT.

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    P3.05 - Poster Session 3 - Preclinical Models of Therapeutics/Imaging (ID 159)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Biology
    • Presentations: 1
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      P3.05-013 - Effect of PsA derivatives on DNA methyltransferase (DNMT) inhibition and radiosensitization in A549 lung cancer cell line (ID 2214)

      09:30 - 09:30  |  Author(s): H.J. Kim

      • Abstract

      Background
      Psammplin A (PsA), a novel DNA methyltransferase (DNMT) inhibitor and histone deacetylase (HDAC) inhibitor, was reported to induce radiosensitivity in lung cancer cell line. Concerning in vivo tissue distribution characteristics, PsA was found to be highly distributed to lung tissues. However, it appeared to be unstable in biological matrices. Here we report the DNMT inhibitory effect of PsA derivatives and their potential for radiation sensitization in lung cancer cell line.

      Methods
      A549 lung cancer cell line was used in verification of DNMT inhibitory effect with cultured cell DNA extraction kit. A549 cell line was exposed to radiation with or without a total of 9 PsA derivatives for 18 hours prior to radiation, after which cell survival was evaluated via clonogenic assays.

      Results
      These 9 PsA derivatives all showed DNMT inhibitory effect and inhibited cell proliferation at the ranges of IC50 30–120μM. Furthermore, radiation clonogenic assays revealed that these compound shows radiosensitizing properties in A549 lung cancer cell line.

      Conclusion
      This preliminary data support the further investigation of these derivatives for use as radiation sensitizing agents with potential for clinical application.