Author of

• 11673

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  P2.09 - Poster Session 2 - Combined Modality (ID 213)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Combined Modality
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11685

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    P2.09-012 - Prognostic Value of Tumor Survivin Expression in Stage III Non-small Cell Lung Cancer Patients Treated with Platinum-based Chemoradiation Therapy Followed by Surgery (ID 2473)

    09:30 - 09:30  |  Author(s): H.J. Cho
    • Abstract

    Background
    The potential prognostic value of survivin is variably reported in various stage of lung cancer. This study evaluated the correlation between tumor survivin expression before and after chemoradiation therapy (CRT) and prognosis in stage III non-small cell lung cancer (NSCLC) patients treated with platinum-based chemoradiation therapy followed by surgery

    Methods
    Medical records from 53 patients whose tissues were suitable for study were reviewed. Tissues were stained by immunohistochemistry and were estimated the degree of stain with scoring for survivin. Clinicopathologic parameters and survivin expression score were evaluated for a prognostic relationship with overall survival (OS) and time to recurrence (TTR).

    Results
    Pathologic complete response, residual nodal involvement and radiologic response after CRT were not related with OS or TTR. Tumor survivin expression on pre-treatment tissues was presented in 47 patients (88.7%). Pre-treatment survivin score was not related with TTR and OS (p = 0.249 and p = 0.601, respectively). There was no correlation between pre-treatment and post-treatment survivin score (p = 0.309). Downregulation of survivin and post-treatment survivin score (0 – 1) after chemoradiation showed significant improvement in OS (p = 0.04 and p = 0.033, respectively). Age, downregulation of survivin score, and post-treatment survivin score (0 – 1) were significant prognostic factors for survival by multivariate analysis.

    Conclusion
    Downregulation of survivin score and post-treatment low survivin score in stage III NSCLC treated with platinum-based chemoradiation therapy followed by surgery has a value of prognostic factor regardless pre-treatment survivin score. Further studies to evaluate the relation of survivin expression and platinum-based chemoradiation therapy are warranted in NSCLC.