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G.K. Ho
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P2.08 - Poster Session 2 - Radiotherapy (ID 198)
- Event: WCLC 2013
- Type: Poster Session
- Track: Radiation Oncology + Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level
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P2.08-022 - Non-Small Cell Lung Cancer (NSCLC): Changes in volume during radiotherapy and potential adaptive radiotherapy planning (ID 2511)
09:30 - 09:30 | Author(s): G.K. Ho
- Abstract
Background
Curative radiotherapy for non-small cell lung cancer (NSCLC) is usually delivered over a time period of 5-7 weeks. Tumour regression has been observed over the course of curative radiotherapy. Currently, the entire radiotherapy treatment is delivered based on the original tumour volume. An evolving approach is adaptive radiotherapy planning whereby the radiotherapy plan is modified during a course of treatment to account for tumour and patient changes. This has the potential to reduce the size of radiotherapy fields, allowing dose escalation and normal tissue sparing.Methods
A cohort of 20 consecutive NSCLC patients receiving a curative course of radiotherapy and who had weekly kV cone beam computer tomography (CBCT) images was identified. The gross tumour volume (GTV) and anatomical reference points were delineated on all CBCT scans. Volume and positional changes were recorded and analyzed.Results
Six patients with non-small cell lung cancer who received curative radiotherapy were assessed so far. Five patients had sufficient image quality for contouring. There was a mean percent decrease of 24.8% by fraction 16 and 37.2% by fraction 26. Average tumour migration was 0.4cm. Progressive anatomical changes were more prominent where there was tumour associated with atelectasis. Updated results for the whole cohort will be presented.Conclusion
Tumour regression was observed in all patients and a proportion showed significant reduction. Adaptive planning was a feasible option in selected patients.
