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M. Nielsen



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    P2.08 - Poster Session 2 - Radiotherapy (ID 198)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Radiation Oncology + Radiotherapy
    • Presentations: 1
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      P2.08-014 - The influence of age on the outcome of concurrent chemo-radiotherapy in locally advanced NSCLC (ID 1677)

      09:30 - 09:30  |  Author(s): M. Nielsen

      • Abstract

      Background
      Concomitant chemo-radiotherapy (CRT) has been shown to be superior to single modality radiotherapy (RT) and to neoadjuvant chemotherapy (NeoCT) followed by RT. In this retrospective study we report the influence of age on survival in two groups of patients with locally advanced radiotherapy treated from 1995 to June 2012: 1) NoCRT-group: RT +/- NeoCT without CRT and 2) CRT-group: NeoCT followed by CRT.

      Methods
      Data for 446 patients that completed 3-D conformal RT or IMRT in planned doses of 60-66 Gy at 2 Gy/F without elective nodal irradiation was obtained. CRT was used for 114 patients with the regimens: weekly Docetaxel (N=43), Carboplatin-Vinorelbine (N=70) and Cisplatin-Vinorelbine (N=1). The NoCRT group consisted of 332 patients

      Results
      Figure 1 The median and 5 year survival was 17.2 months and 15% for NoCRT, and 21.4 months and 29% for CRT (p<0.02). The data was analyzed in the age groups ≤65 and >65 years. For NoCRT, no differences in survival was found (17.2 vs. 17.1 months), but in the CRT group significant longer survival was found in the younger age group, 29.2 vs. 20.0 months in the older group (p=0.03). CRT was the only significant factor among patients ≤65, while CRT was an insignificant factor among patients >65. The patients treated with CRT had significantly lower frequency of local relapse (33%) compared with patients treated without (46%, p = 0.016), while the rate of distant metastases was unaffected by the use of CRT. Patients ≤65 years had a low complication death rate (1-2%) independent of CRT, while the complication death rate among patients >65 years was 6-8%, also independent of CRT.

      Conclusion
      Patients ≤65 years had a very positive effect of CRT while CRT did not influence survival in older patients. The reason for this is unknown