Author of

• 11595

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  P2.07 - Poster Session 2 - Surgery (ID 190)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11634

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    P2.07-039 - Survival outcome of Patients undergoing Surgical Resection of NSCLC in Brunei Darussalam (ID 3073)

    09:30 - 09:30  |  Author(s): C.F. Chong
    • Abstract

    Background
    Lung cancer is the leading cause of cancer deaths in Brunei Darussalam for the past 5 years. Curative surgical resection in early stage non-small cell lung cancer (NSCLC) have been shown to improve survival. This study aimed to assess the 5-yr survival of patients undergoing surgical resection of NSCLC in Brunei Darussalam.

    Methods
    From 2000 to 2013, 64 patients underwent surgical resection of NSCLC at the RIPAS Hospital in Brunei Darussalam. Demographic and Clinical data of these 64 patients were retrospectively retrieved from the clinical notes. All deaths and date of death were obtained and cross-check with the National birth and death registry at the Imigration Department. Data were analysed using SPSS statistical software and 5-yr Kaplan-Meier survival curves were derived. Predictors of 5-yr survival were analysed using Cox regression analysis.

    Results
    Mean age of the 64 patients was 60.6 ± 12.2 (27.4 – 80.0 years) with male to female ratio of 39:25. Racial distribution consisted of 82.9% (53/64) Malay, 15.6% (10/64) Chinese and 1 foreign national. Histological types of NSCLC consisted of 57.8% (37/64) adenocarcinoma, 12.5% (8/64) Squamous cell carcinoma, 4.7% (3/64) large cell carcinoma, 18.8% (12/64) bronchioalveolar carcinoma and 6.3% of other origin. Overall 5-yr Kaplan-Meier survival curves according to stage of disease were 67.9% for Stage 1A, 51.1% for Stage 1B, 30.0% for Stage 2B, 29.0% for Stage 3A, 20.8% for Stage 3B and 33.3% for Stage 4. 5-yr disease-free survival were 59.6% for stage 1A, 43.5% for stage 1B, 20.8% for Stage 3B and 33.3% for stage 4. 5-yr survival for Stage 1A was better in patients who had systematic mediastinal lymphnodes dissection carried out as routine procedure (72.5%). Only Stage of NSCLC at the time of surgery was a significant independent predictor of 5-yr survival (p=0.01).

    Conclusion
    Overall 5-yr survival of patients with treated early stage 1A NSCLC is good and comparable to the surrounding region. This is further improve if routine SMLD were performed. Stage of NSCLC at time of diagnosis was the only significant independent predictor of 5-yr survival.