Author of

• 11543

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  P2.06 - Poster Session 2 - Prognostic and Predictive Biomarkers (ID 165)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Biology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11550

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    P2.06-007 - Meta-Analysis of STAT3 and p-STAT3 Expression and Survival in Non-Small-Cell Lung Cancer (ID 786)

    09:30 - 09:30  |  Author(s): B. Cheng
    • Abstract

    Background
    The prognostic role of signal transducer and activator of transcription 3 (STAT3) and phosphorylated STAT3(p-STAT3) in non-small-cell lung cancer (NSCLC) remains controversial. To clarify its impact on survival, we performed a meta-analysis to quantitatively assess STAT3 and p-STAT3 expression on prognosis of NSCLC.

    Methods
    Published studies were identified using a systematic and thorough literature search.To be eligible, a study had to investigate STAT3 or p-STAT3 expression rates of NSCLC patients in different characteristics and survival data of STAT3 or p-STAT3 expression.

    Results
    A total of 17 retrospective trials were chosen for meta-analysis, including 1793 patients.We showed that the estimated pooled HR (0.67, 95%CI: 0.57-0.77) of 9 trials (STAT3: HR 0.71, 95%CI 0.38-1.04; p-STAT3: HR 0.67 ,95%CI 0.56-0.77) for NSCLC was statistically significant (P<0.0001), suggesting that high STAT3 or p-STAT3 expression is a strong predictor of poor prognosis among patients with NSCLC.For the risk factors, pooled analysis of patients with STAT3 positivity, demonstrated a statistically significant OR (3.82, 95%CI: 2.37-6.16) between poorly differentiated carcinoma and well-moderately, OR( 5.68, 95%CI: 3.16-10.21)between patients in stage III-IV and patients in stage I-II, and OR (3.41, 95%CI: 2.12-5.49 ) between patients with lymph node metastasis and patients without lymph node metastasis. However, pooled analysis of patients with p-STAT3 positivity, only demonstrated a statistically significant OR (4.51, 95%CI: 1.57-12.96) between poorly differentiated carcinoma and well-moderately(P<0.05).

    Conclusion
    High STAT3 or p-STAT3 expression is a strong predictor of poor prognosis among patients with NSCLC. The conclusion should be confirmed by large prospective studies with long-term follow-up.