Author of

• 11543

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  P2.06 - Poster Session 2 - Prognostic and Predictive Biomarkers (ID 165)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Biology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11547

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    P2.06-004 - Serum levels of MUC1 glycoprotein (ICO25) in primary lung cancer patients (ID 319)

    09:30 - 09:30  |  Author(s): R. Yakubovskaya
    • Abstract

    Background
    The elevated serum level of MUC1 (KL-6, CA15.3) in lung cancer patients is considered to be a marker for advanced adenocarcinoma and a prognostic factor for disease progression after treatment. The aim of this study was to evaluate the serum MUC1 levels in primary lung cancer patients in the Russian Federation, a large portion of which are patients with squamous cell lung cancer (SCC).

    Methods
    Serum samples were obtained from 346 patients at admission. Two hundred ninety three patients were diagnosed with a malignant lung tumor (MLT), i.e. SCC (n=136); adenocarcinoma, AC (n=89); adenosquamous cancer, ASqC (n=21); bronchioloalveolar carcinoma, BAC (n=12); large cell carcinoma, LCC (n=3); small cell cancer (n=4); anaplastic cancer (n=8); carcinoid (n=17); sarcoma (n=3). A non-malignant lung disease (NMLD) was confirmed histologically in 53 patients: benign tumors (n=10), pneumofibrosis (n=13), tuberculosis (n=9), a resolution stage of pneumonia (n=21). Anti-MUC1 ICO25 monoclonal antibody-based and validated inhibition enzyme-linked immunosorbent assay was used (normal range 9 - 38 U/ml, median 24 U/ml).

    Results
    An occurrence of the elevated serum MUC1/ICO25 levels (³40 U/ml) in patients with MLTs was significantly higher than in patients with NMLDs (151 [51.5%] vs. 7 [13.2%] cases, correspondingly; р<0.001), and it positively correlated with clinically aggressive tumor histology: AC, 61.0%; ASqC, 61.9%; SqCC, 44.9%; BAC, 25.0%; LCC and small cell cancer, 100%; anaplastic cancer, 50.0%; carcinoid, 23.5%; sarcoma, 0%. The significantly elevated serum MUC1/ICO25 levels (³60 U/ml) were found in 81 (27.6%) patients with MLTs and 1 (1.9%) patient with NMLDs. In patients with nonsquamous non-small cell lung cancers (AC, BAC, LCC) and ASqC the serum MUC1/ICO25 ³60 U/ml were found in 44.0% (55/125) of cases. The rate of these cases positively correlated with the advanced TNM stage and depended on the patients’ age: statistically significant difference between stages I-II and stages IIIB-IV was found in patients aged 65 years and older (15.8% [3/19] vs. 84.2% [16/19]; p<0.001), but not in patients aged less than 65 years (28.6% [8/28] vs. 48.6% [17/35]; p=0.127). In patients with SCC the overall rate of serum MUC1/ICO25 ³60 U/ml was 16.9% (23/136), and the reversed age-related dependence of those levels on the tumor stage was bserved. In patients aged less than 65 years the higher rate of the serum MUC1/ICO25 ³60 U/ml correlated with more advanced TNM stage: 0% (0/13), 13.8% (4/29),28.6% (6/21) and 52.9% (9/17) for stages I, II, IIIA and IIIB-IV, respectively (I-II vs. IIIB-IV, p<0.001). In patients with SCC aged 65 years or older the serum MUC1/ICO25 ³60 U/ml was found in 0% (0/19), 30.0% (3/10), 7.7% (1/13) and 0% (0/14) of cases for stages I, II, IIIA and IIIB-IV, respectively. In the entire group of patients the rate of the serum MUC1/ICO25 ³60 U/ml did not depend on the tumor histological grade, local tumor extension, location of distant metastases or comorbidities.

    Conclusion
    The abnormal MUC1/ICO25 serum levels correlate with unfavorable prognostic clinical characteristics of the lung cancer, and its potential clinical significance is not restricted to the cases of lung adenocarcinoma.