Author of

• 11454

  +

  P2.01 - Poster Session 2 - Cancer Biology (ID 145)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Biology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/29/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11480

    +

    P2.01-026 - "EGFR" gene mutation in advanced non small cell lung cancer-a case series (ID 833)

    09:30 - 09:30  |  Author(s): M.A. Munawar
    • Abstract

    Background
    Molecular targeted therapy based on TKIs, directed at the Epidural growth factor receptor (EGFR) is one of the recent option for the management of advanced Non-Small Cell Lung Cancer (NSCLCs). EGFR gene mutations, exon 19 deletions (E19 del (LREA deletions)) and exon 21(L858R) are most common and good predictions of response to EGFR-TKI treatment. EGFR gene mutations are found in approx. 10% of Caucasian patients and up to 50% of Asian populations[(1)] .Recent studies have endorsed these incidences in European and Asian populations. The frequency of EGFR mutation is higher in non-smokers and in women[(2,3) ].The aim of the study was to determine the frequency of EGFR gene mutation in advanced non small cell lung cancer patients presenting to SKMCH & RC.

    Methods
    Between Sep 2011 to Sep 2012, we have sent EGFR Mutation testing for 15 patients with proven histology of TTF-1 positive adenocarcinoma lung. EGFR gene mutations in exons 18, 19,20 and 21 were carried out by National University Hospital Singapore and Singapore General Hospital. Data was collected and analysed. Frequencies were determined.

    Results
    10 (66.6 %) patients were male and 5 (33.3 %) were females. Eight (53.3 %) were smokers and 7 (46.6 %) were non smokers.Three (20 %) patients were having EGFR mutation +ve . One with +ve mutation on exon 19, one with +ve mutation on exon 21 and one with +ve EGFR mutation on exon 20. Two of these three( 66.6%) patients were smoker and one ( 33.3%)out of them was non smoker. All three patients were male. One (6.6%) patient has insufficient biopsy material to carry out the test. While 8 (53.3 %) patients have –ve EGFR mutation on all exons and 3 (20%) patients have unsatisfactory results on few exons and –ve mutation on other exons.

    Conclusion
    The frequency of EGFR mutation in our institution was 20 % and all these patients were male, two third patients were smokers. This trend is not in accordance with literature, needs more number of patients to find out the real trend.