Author of

• 11001

  +

  P1.24 - Poster Session 1 - Clinical Care (ID 146)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 11050

    +

    P1.24-049 - Comparison of information provided by the lung cancer pts through the survey with the Physician's evaluation. (ID 3230)

    09:30 - 09:30  |  Author(s): O. Mareca
    • Abstract

    Background
    Various factors such as age, stage and PS may provide prognostic information in advanced NSCLC; however, a better understanding of a patient’s judgement can help the Physician to make appropriate decisions.Purpose:1- To study the information provided by pts in a questionnaire. 2 To study PS evolution obtained by the doctor (DPS) and by the pts themselves (PPS).3-To evaluate the correlation between some different variables with survival.

    Methods
    Patients and Method: 224 pts with stages III and IV NSCLC, age range 38 - 74 years, were studied. The study was prospective. Pts underwent chemotherapy and/ or radiotherapy. They determined their own PS through a questionnaire . Some different variables such as age, stage, DPS, PSP, appetite, food intake, amount of solid food, evening meals, average meal per day, serving size, vomiting frequency, daily work activity , activity restrictions, and hours of rest per day were analyzed . DPS and PPS were studied at diagnosis and at 3 months. Statistical methods: Cox Proportional-Hazards Regression, Chi Square Pearson, Irwin-Fisher,Mac Nemar Wilcoxon tests and Kaplan Meier Curves were used.

    Results
    Results: According to the univariate logrank test applied to the comparison of the Kaplan and Meier survival curves, many factors seem to be related to survival. 9 of all variables studied were statistically significant. There were no complete agreement between DPS and PPS neither at initial evaluation nor at 3 months. Pts’ self assessment showed higher PS score than PS obtained by doctors.(Mac Nemar Test p< 0.0001).The correlation among predictor variables is not taken into account when using the univariate approach, so a Cox hazard model for the proportional risk was adjusted using all the predictor variables available. To eliminate the less prognostic variables a backward regression test was applied It was found that only initial WL and DPS at the third month of evaluation were positively related to the risk of death. However the low correlation between WL as well asDPS provide independent information.there was statistically significant association between response rate with DPS and PPS. Nutritional parameters revealed no significant data.

    Conclusion
    : Although the univariate approach showed that many factors are related to the survival of pts, the simultaneous analysis of these factors through the Cox model revealed that few of them summarize the most relevant prognostic information. These variables are DPS at the third month of evaluation and initial WL.