Author of

• 10974

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  P1.21 - Poster Session 1 - Diagnosis and Staging (ID 169)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Prevention & Epidemiology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10979

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    P1.21-005 - Multiple primary malignancies in patients with lung cancer: clinical features and prognosis (ID 2074)

    09:30 - 09:30  |  Author(s): Y.J. Ryu
    • Abstract

    Background
    BACKGROUNDS: The development of multiple synchronous primary malignancies in an individual is uncommon and unfortunate, but the frequency is increasing. The metachronous cancers will appear more commonly as cancer patients live longer lives. OBJECTIVES: The aim of this study was to determine clinical features, organ location, and prognosis in patients with multiple primary malignancies (MPM) including lung cancer.

    Methods
    METHODS: Following a retrospective review of clinical data, 101 patients with MPM including lung cancer confirmed with a histopathological diagnosis between 2002 and 2012 were enrolled in a tertiary referral hospital.

    Results
    RESULTS: The median age was 67 years (interquartile range (IQR), 61-73 years) at lung cancer diagnosis, and 66 (65%) patients were male. The most common histologic type of lung cancer was adenocarcinoma (47%), and 5 patients (5%) were diagnosed with triple cancers. In a total 56 metachronous cancer (55%), the median time between lung cancer and other cancer was 47.1 months (IQR 23.6-72.1 months) and 20 had lung cancer diagnosed before the occurrence of other primary cancers. The synchronous tumors were in 45 of 101 (46%). The most frequent cancers accompanying lung cancer were urogenital malignancies (30%) followed by gastrointestinal tract (28%) and thyroid malignancies (17%). Median survival duration calculated from the diagnosis of the first cancer was 33 months in the lung cancer first patients, 11 months in the other cancer first patients and 1.5 months in synchronous patients (p ≤ 0.001) with median follow up of 12.2 months. The factors of significantly associated with the survival of MPM were adenocarcinoma; histologic type of lung cancer (p = 0.010), the initial intensive treatments of lung cancer (p ≤ 0.001), non-smoker (p = 0.045) and operable lung cancer stage (p = 0.049) using Kaplan–Meier method with the log-rank test.

    Conclusion
    CONCLUSION: The synchronous tumors showed worse outcomes compared with those of the metachronous tumors including lung cancer. Despite multiple primary malignancies in patients with lung cancer, the influence of effective anticancer therapies that improve the survival, and the prognostic factors including the histologic type, staging, and smoking status were similar to the known factors of lung cancer.