Author of

• 10962

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  P1.20 - Poster Session 1 - Early Detection and Screening (ID 172)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10969

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    P1.20-007 - Low-Dose Computed Tomographic Screening in Healthy Adults at Low Risk for Lung Cancer (ID 2661)

    09:30 - 09:30  |  Author(s): Y.Y. Cho
    • Abstract

    Background
    The benefit of low-dose CT screening was proved by showing reduced mortality from lung cancer in persons at high risk for lung cancer. We evaluated the effect of low-dose CT screening in healthy adults at low risk for lung cancer.

    Methods
    From January 2006 through December 2008, we retrospectively enrolled 13,085 symptom-free healthy adults who underwent three annual screenings with either low-dose CT (6,256 persons) or chest radiography (6,829) for regular check-ups. They were divided into groups at high risk (≥30 pack-year smoking and ≥ 55 years), intermediate risk (≥20 pack-year smoking and ≥ 50 years), or low risk (<20 pack-year smoking). Data were collected on numbers of screening detected lung cancer and survival from screening detected lung cancer that occurred through December 31, 2012.

    Results
    The rate of positive screening test was 53.2% with low-dose CT and 13.1% with radiography. A total of 98.2% of the positive screening results in CT group and 97.9% in radiography group were false positive results. CT screening increased the number of screening detected lung cancers in the less than high risk population (multivariable-adjusted odds ratio (OR) 4.75, 95% confidence interval (CI) 2.56 to 8.82, P <.001), but not in high risk population (OR 1.23, CI 0.38 to 3.93, P =.730). In the less than high risk population CT screening detected lung cancers were all adenocarcinomas and were more frequently part-solid or non-solid nodules (P=.008). The stage of CT screening detected lung cancer more commonly in IA disease (76.1% in CT vs. 20% in radiography, P <.001) and the survival of CT screening detected lung cancer was consistently better than radiography screening detected lung cancers in the less than high risk population (multivariable-adjusted hazard ratio (HR) 0.08, CI 0.01 to 0.60, P =.014), in the less than intermediate risk population (HR 0.07, CI 0.01 to 0.66, P =.021), and in the low risk population (HR 0.07, CI 0.01 to 0.69, P =.023).

    Conclusion
    CT screening in low risk population detected more number of stage IA adenocarcinomas which area more frequently part-solid or nonsolid nodules, as compared with chest radiography or with CT in high risk population. The survival of CT screening detected lung cancer was better than that of chest radiography detected lung cancers in the lower risk population.