Author of

• 10962

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  P1.20 - Poster Session 1 - Early Detection and Screening (ID 172)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10964

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    P1.20-002 - Elevated Inflammatory Markers Could be Useful In Early Diagnosing And Monitoring Lung Cancer (ID 1365)

    09:30 - 09:30  |  Author(s): G. Demirag
    • Abstract

    Background
    Background: Lung cancer is still the first leading cause of cancer death worldwide, and late diagnosis is a major obstacle to improving lung cancer outcomes. Tumor inflammation and immunology are recently identified as enabling cancer characteristics and play important roles in tumor progression and metastasis. Recently, elevated preoperative or pretreatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio(PLR) and mean platelet volume (MPV) detected in peripheral blood were identified as independent prognostic factors associated with poor survival in various cancers, including colon cancer, esophageal cancer, gastric cancer and breast cancer. These markers are highly repeatable, inexpensive and widely available. The aim of this study is to examine whether MPV, NLR and PLR could be useful inflammatory markers for differentiating lung cancer from healthy controls; also to determine the relation between these markers and other prognostic factors and histopathologic subgroups.

    Methods
    Methods: Retrospectively eighty-one lung cancer patients and 81 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. The preoperative or pretreatment blood count data was obtained from the recorded computerized database.

    Results
    Results: NLR and PLR values were significantly higher in lung cancer patients compared to healthy subjects.( NLR: 4.42 vs 2.45 p=0.001, PLR: 245.1 vs. 148.2 p= 0.002) MPV values were similar in two study groups (7.7 vs. 7.8). On the other hand we did not find statistically significant relationship between these markers ( MPV, NLRand PLR) and histopathologic subgroups, TNM stages, grade, OS and PFS (all p>0.05).

    Conclusion
    Conclusion: Our data suggests that NLR and PLR values may be used as easily and available biomarkers for early diagnosis of lung cancer, but needs more large prospective studies to predict patients outcome.