Author of

• 10946

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  P1.19 - Poster Session 1 - Imaging (ID 179)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10955

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    P1.19-009 - Differences in proliferation of tumor cells in ground-glass opacity lesions on computed tomography for primary non-small cell lung cancer (ID 2801)

    09:30 - 09:30  |  Author(s): K. Takahashi
    • Abstract

    Background
    Ground-glass opacities (GGOs) on computed tomography (CT) represent a distinctive finding for nodules of bronchioloalveolar carcinoma that are generally stable or growing very slowly due to a low degree of malignancy. Therefore, small GGOs are often followed conservatively. However, some GGO nodules undergo clear enlargement during follow-up. The present study aimed to define the clinical features of GGO with potentially high degree of malignancy.

    Methods
    Among patients who underwent surgery for non-small cell carcinoma between June 2010 and April 2013 in our hospital, all 28 patients with GGO or mixed GGO nodules who had been prospectively evaluated with high-resolution computed tomography (CT) were enrolled in this study. Immunohistochemical studies using MIB-1 antibody to evaluate cell proliferation were performed using specimens obtained from GGO parts of 6 pure GGO and 22 mixed GGO nodules. A high-proliferation group was defined as cases showing >10% positive cells. The following clinical parameters were assessed: sex; age; smoking history; tumor size; tumor shape; tumor contour; ratio of consolidation area to whole area of tumor; and density of GGO. Correlations between high-proliferation status and clinical parameters were analyzed using Fisher’s exact probability test.

    Results
    Median frequency of positive cells by immunohistochemistry for MIB-1 was 9% (range, 1-42%) and the high proliferation group comprised 10 cases (35.7%). This group correlated significantly with high-density GGO, defined as showing a difference >400 Hounsfield units between the GGO field and adjacent lung field (P=0.038), and tended to correlate with tumor diameter >20 mm (P=0.095).

    Conclusion
    Density of GGO lesions correlates with proliferation of tumor cells. This clinical feature appears likely to allow differentiation of high-risk patients with GGO lesions.