Author of

• 10946

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  P1.19 - Poster Session 1 - Imaging (ID 179)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Imaging, Staging & Screening
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10947

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    P1.19-001 - Inhaled Cisplatin Displayed with the CytoViva Technique in Stage II Non-Small Cell Lung Cancer Patients (ID 160)

    09:30 - 09:30  |  Author(s): W. Hohenforst-Schmidt
    • Abstract

    Background
    Lung cancer therapies during the last decade are targeting the genome of cancer cells. However, investigating the gene pathways of tumor has the disadvantage so far that mutations are found in a limited number of patients therefore limiting the production of targeting therapies. Novel routes for administering lung cancer therapies have been investigated for decades. Aerosol therapies for several systematic diseases and systemic infections have been introduced in the market for a decade. One of the main issues of aerosol therapies has been the investigation of the deposition of a drug compound throughout the systematic circulation and lymph node circulation. Until now none of the published studies have efficiently displayed the deposition of a chemotherapy pharmaceutical within the lymph node tissue.

    Methods
    The CytoViva[®] technique can be summarized to the following information. Optical and hyperspectral images along with hyperspectral data were captured utilizing a research grade optical microscope equipped with the CytoViva[®] advanced darkfield illumination system, dual mode fluorescence module and integrated hyperspectral imaging system. This integrated system builds hyperspectral image files via “push broom” method, enabling the creation of a high signal to noise spectral image file. Subsequent image analysis delineates the reflectance spectral response of the sample elements in each nanoscale pixel of the image file.

    Results
    Figure 1 First picture represents an optical image lymph node station 7 after inhaled cisplatin. Second image represents spectral image of lymph node station 7 red areas represent the cisplatin diffusion within the tissue. Third image spectral library of inhaled cisplatin (90minutes after aerosol cisplatin administration, 40mg) The concentration 90 minutes after the aerosol cisplatin administration (40mg) was 2.09 μg/g Pt. in lymph node station 7 as measured with biochemistry techniques in a second patient.

    Conclusion
    We have efficiently presented data correlating at the same time local deposition with diffusion of aerosol cisplatin and concentration within lymphnodes. Using an optical technique and a biochemistry technique. Aerosol chemotherapy is an efficient method of treatment and further investigation is warranted with or without additional carriers added to the drug formulation.