Author of

• 10907

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  P1.16 - Poster Session 1 - Other Thoracic Malignancies (ID 186)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Thymoma & Other Thoracic Malignancies
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10908

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    P1.16-001 - Outcomes of surgical resection and radiofrequency ablation for lung metastasis from hepatocellular carcinoma (ID 1219)

    09:30 - 09:30  |  Author(s): T. Niguma
    • Abstract

    Background
    The lung is the most frequently targeted organ for extra-hepatic metastasis from hepatocellular carcinoma (HCC). Pulmonary metastases account for 33.1% of extra-hepatic metastases from HCC. However, in most cases, pulmonary metastatic lesions are multiple and the prognosis of patients is poor. No standardized treatment for this condition has been established to date. Radiofrequency ablation (RFA) is commonly used for the local control of hepatic tumors. Recently, computed tomography-guided RFA has been indicated for lung tumors, and promising results have been reported. We analyzed the outcomes of surgical resection and RFA, used either alone or consecutively, for pulmonary metastatic lesions from HCC.

    Methods
    Eleven patients with lung metastasis from HCC underwent surgical resection alone, RFA alone, or surgical resection followed by RFA for pulmonary metastases from HCC. The initial treatment for pulmonary metastasis was surgical resection in 7 cases and RFA in 4 cases. Two patients who underwent surgical resection as initial treatment also received RFA. Seven patients were male, and the average age at initial treatment for the lung lesions was 69.8 years (range, 50–78 years). Surgical resection was indicated especially for lesions close to the visceral pleura and RFA was indicated for relatively medial lesions.

    Results
    The average number of metastases per patient was 1.8 (range, 1–4). Tumor size ranged from 5 to 40 mm. No treatment-related deaths or severe complications were noted. The median survival time for all cases was 25 months. Three patients survived for more than 3 years after initial treatment. Of these 3 patients, 2 underwent both metastectomy and RFA and 1 underwent metastectomy alone. At initial presentation, none of these 3 patients had extra-pulmonary lesions and all 3 patients had solitary lung metastatic lesions.

    Conclusion
    Local therapy comprising surgical resection, RFA, or both might be beneficial for the treatment of lung metastasis from HCC in cases with no extra-pulmonary lesions and few lung lesions. RFA is minimally invasive and can be performed under local anesthesia, without the loss of lung volume.