Author of

• 10874

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  P1.13 - Poster Session 1 - SCLC (ID 200)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10876

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    P1.13-002 - Prognostic Value of 18F-fluorodeoxyglucose Uptake in Small Cell Lung Cancer Patients Treated with Concomitant Chemo-radiotherapy or Chemotherapy alone (ID 1277)

    09:30 - 09:30  |  Author(s): D. Binns
    • Abstract

    Background
    There is some evidence that the standard uptake value (SUV) measured using 18F- fluorodeoxyglucose positron emission tomography ([18]FDG-PET) in patients with non-small cell lung cancer (NSCLC) may be prognostic for survival. Small cell lung cancer (SCLC) clinically differs from NSCLC by its rapid proliferation and is staged as either limited disease (LD) defined as disease confined to one hemithorax and the regional lymph nodes or extensive disease (ED) which is disease that has spread beyond this. There is much less information available on the potential prognostic value of the SUV obtained during [18]FDG-PET scanning in SCLC. This study thus aims to explore whether SUV can be effective in the prognostic stratification of SCLC patients with LD and ED.

    Methods
    Retrospective study of patients diagnosed with SCLC who underwent a pre-treatment 18FDG-PET scan between 1999 – 2008 at the Peter MacCallum Cancer Centre and 2004 -2011 at the Austin Hospital. Patients with LD were treated with radical concomitant chemo-radiotherapy and those with ED treated with chemotherapy alone. Maximum and mean SUVs were retrieved, and survival of patients measured. The correlation between SUV and other patients’ clinicopathological factors, including age, sex, performance status, weight loss and tumour stage (TNM) were also explored.

    Results
    Thirty-six eligible patients were identified, with a median follow-up of 14 months (range, 3-103 months). There were 23 males and 13 females. The median age was 69 years (55-84 years). Twenty patients had LD and 16 had ED. Thirteen patients had stage IV disease and 10 patients each had stage IIIA and IIIB disease (3 patients were unable to be staged according to TNM classification system). Higher TNM stage was associated with higher SUVmax (r~s~=0.37, p=0.036) but not with SUVmean (r~s~=0.30, p=0.086). There was no evidence of a significant association between clinicopathological factors with SUVmax in patients with LD and ED, except for age in patients with ED. Increasing age was associated with higher SUVmax (r~s~=0.72, p=0.002) and higher SUVmean in patients with ED (r~s~=0.81, p<0.001). SUVmax and SUVmean were not significantly associated with OS in patients with LD or ED or in the whole sample.

    Conclusion
    In patients with SCLC there was an association between higher SUVmax and higher TNM stage, as observed in patients with NSCLC. However, in this small patient cohort, we were unable to find evidence of an independent prognostic effect of SUVmax on overall survival.