Author of

• 10850

  +

  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10872

    +

    P1.12-022 - Predictive value of SUV max/invasive size ratio in the subtypes of lung adenocarcinoma (ID 3186)

    09:30 - 09:30  |  Author(s): J. Lee
    • Abstract

    Background
    In lung adenocarcinoma, prognostic importance of maximum standardized uptake (SUV max) value on positron emission tomography (PET) has been well observed. Different subtypes had different 18F-fluorodeoxyglucose (FDG) uptake, and it was also related with tumor size. The ratio of SUV max and tumor size was supposed to be different depending on the subtypes of lung adenocarcinoma.

    Methods
    Medical records of the lung adenocarcinoma patients who underwent surgery in Seoul National University Bundang Hospital between 2003 and 2012 were reviewed. Ratio of SUV max and invasive tumor sizes was calculated and categorized into two groups. Group 1 included patients of ratio < 1.5, and Group 2 included the rest. The subtypes of lung adenocarcinoma were categorized into 4 groups; solid, acinar, lepidic, papillary according to their pathologic reports. Overall survival and disease-free survival rates of Group 1 and 2 were compared in each predominant subtype patients.

    Results
    Total number of patients was 680. The average ratio of SUV max/invasive size was 1.63. The ratio of SUV max/invasive size of solid subtype was 2.48 and it was significantly higher than acinar and lepidic subtypes. (p<0.000) Overall survival (OS) and disease-free (DF) survival of lepidic subtype were 39.3 months and 41.4 months each, and were significantly higher than solid and acinar subtypes. OS and DF of Group 1 were 36.4 and 32.8 each. Those of Group 2 were 29.8 and 21.6 months. Group 1 had significantly longer OS and DF than Group 2. (p<0.000, and p=0.001 each) In solid subtype, OS and DF of Group 1 were 32.8 and 27.7 months and those of Group 2 were 22.7 and 17.6. But there were no significant differences. (p=0.117 and p=0.123 each) In acinar subtype, OS and DF of Group 1 were 38.2 and 34.4 months, those of Group 2 were 32.9 and 24.3 months. The differences were statistically significant. (p<0.000, p=0.023, each) Three-year overall survival rates and 3-year disease-free survival of Group 1 were 45.2% and 39.1%. Those survival rates of Group 2 were 32.2% and 19.2% respectively. Recurrence hazard ratio of Group 2 was 1.68. (p<0.000, 95% confidence interval 1.379-2.061) In acinar subtype, recurrence hazard ratio of Group 2 was 1.83 and there was significant difference. (95% confidence interval: 1.410-2.381, p< 0.000) In other subtypes, recurrence hazard ratio showed no significant differences.

    Conclusion
    Ratio of SUV max and invasive tumor size had limited prognostic value in subtypes of lung adenocarcinoma. It could be used as a prognostic factor for recurrence in acinar predominant subtype category.