Author of

• 10850

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  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10869

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    P1.12-019 - Survival analysis of 106 female patients with completely resected lung adenocarcinoma in Shaanxi province (ID 2671)

    09:30 - 09:30  |  Author(s): S. Li
    • Abstract

    Background
    The female patients with Non-small cell lung cancer in China have higher mortality than in the most of other countries. And the main pathological type is adenocarcinoma. Even though after complete resection, these patients still have an unsatisfactory prognosis. We retrospectively analyzed prognostic factors of 106 female patients with completely resected lung adenocarcinoma in Shaanxi province to find patients with unfavorable factors for proper management.

    Methods
    Clinical data of 106 female patients with complete resection of lung adenocarcinoma at Shaanxi Provincial People’s Hospital between January 2003 and December 2010 were reviewed retrospectively and analyzed the effect of factors about age, with symptoms or not, operation types, the maximum-diameter of tumor, postoperational pathological stage, dissected lymph nodes, the adjuvant therapy and the recurrence or metastasis on 5-year overall survival(OS). Cumulative survival was analyzed by the Kaplan-Meier method and compared by log-rank test. Prognosis was analyzed by the Cox proportional hazards model.

    Results
    The overall 5-year survival rates were 57.0%. 38(35.8%) of the 106 patients had recurrence or metastasis. A univariate analysis demonstrated that age(>54 years), postoperational pathological stage, the total number of removed lymph nodes(>12), the total number of removed N1 lymph nodes(>7), the total number of removed N2 lymph nodes(>7), the number of involved N2 lymph nodes(>2), removed N2 stations(>2), the adjuvant therapy and the recurrence or metastasis were significant prognostic factors for 5-year OS. In the multivariate analysis, the total number of removed N2 lymph nodes(>7) and the recurrence or metastasis were independent prognostic factors for 5-year OS.

    Conclusion
    For female patients with completely resectable lung adenocarcinoma in Shaanxi province, it is very important to give systematic mediastinal lymphadenectomy，7 and more N2 lymph nodes should be removed during surgical resection. The individual adjuvant therapy and the intensive follow-up should be given to the patients with the high risk for the recurrence or metastasis. Total number of removed N2 lymph nodes ＞7 was the favorable prognostic factor and the recurrence or metastasis was the adverse one.