Author of

• 10850

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  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10865

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    P1.12-015 - Prognostic impact of the amount of tobacco smoking in patients with resected non-small cell lung cancer (ID 2258)

    09:30 - 09:30  |  Author(s): T. Okamoto
    • Abstract

    Background
    The purpose of this study was to investigate the relationship between the amounts of tobacco smoking and the clinicopathological features of non-small cell lung cancer (NSCLC) patients.

    Methods
    We retrospectively reviewed the clinical records of 1825 consecutive NSCLC patients who underwent surgery in our department. Among them, the data sets of 363 squamous cell carcinoma (Sq) patients and 720 adenocarcinoma (Ad) patients who received lobectomy or more extensive resection were available. The definitions of smokers used in the study were: light smoker had a smoking history of 30 pack-years (PY) or less, heavy smokers had a history of more than 30 to 60 PY and super-heavy smokers had a history of more than 60 PY. The survival curves were estimated according to the Kaplan-Meier method and were assessed by the log-rank test. A multivariate survival analysis was performed using the Cox proportional hazards model. Differences were considered to be statistically significant for values of P < 0.05.

    Results
    There were more male patients, more aggressive operations (bi-lobectomy or pneumonectomy) and heavier smokers in the Sq patients than Ad patients (p< 0.0001, p=0.012 and p<0.0001). In Ad patients, the never-smokers (n=309) were more likely to be female, to have less advanced stage tumors and had a significantly better prognosis than ever-smokers (n= 441) (five-year OS: never-smokers, 67.9%; smokers, 53.7%, p<0.0001). In Sq patients, the never-smokers (n=15) were more likely to be female than the ever-smokers (n=348). There was no significant prognostic difference between never-smokers and ever-smokers in the Sq patients (five-year OS: never-smokers, 28.6%; ever-smokers, 46.7%, p=0.36). Among ever-smokers, the light-smokers (n=56) had more female patients, more advanced stage tumors and a significantly worse prognosis than heavy smokers (n=292) (p = 0.0003). The multivariate survival analysis showed that light smoking was related to a worse prognosis compared to heavy smoking (HR=2.06, 96%CI 1.43-2.98, p=0.0001).

    Conclusion
    The never-smokers had a better prognosis than ever-smokers in Ad patients, whereas the light-smokers (PY ≤ 30) had a significantly worse prognosis than heavier smokers (PY > 30) in Sq patients. There might be other factors than tobacco carcinogens that influence the development of squamous cell carcinoma in light smokers.