Author of

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  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

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    P1.12-013 - Limited resection for solid non small cell lung cancers provides worse outcome despite of clinical early stage. (ID 2137)

    09:30 - 09:30  |  Author(s): H.J. Park
    • Abstract

    Background
    In recent years, Limited resection for ground glass opacity lesions is not inferior to lobectomy. However, the effect of limited resection on solid type early lung cancer is controversial. The aim of this study was to compare clinical outcomes of patients with solid type early stage non small cell lung cancer undergoing limited resection or lobectomy.

    Methods
    This is a retrospective study between March 2000 and September 2010. the patients with ground glass opacity lesion were excluded. Medical records of 164 patients with clinical stage IA were reviewed. 31 patients underwent limited resection and 133 patients underwent Lobectomy Disease free survival and overall survival were estimated by Kaplan Meier methods Prognostic factors associated with disease free survival and overall survival were analyzed by the Cox proportional hazards model.

    Results
    Limited resection group had medical comobidities significantly including old age (p<0.001), cardiovascular disease (p=0.001) and lower diffusing capacity of the lung for carbon monoide (p<0.001). The lobectomy was associated with longer disease free survival and overall survival (p=0.001) By multivariate analysis, Sublobar resection (p=0.011), lymphatic vessel invasion (p=0.006), and number of positive lymph nodes (p=0.028) were predictors for survival. Sublobar resection (p<0.001), visceral pleural invasion (p=0.002), and lymphatic vessel invasion (p<0.001) were predictors for disease-free interval.

    Conclusion
    Solid-type lung cancers demonstrated aggressive behavior and there were numerous significant pathologic prognostic factors in clinical stage IA NSCLC from our study. Lymph node metastasis was not rare in clinical stage IA NSCLC with a solid component. Lobectomy with lymph node dissection remains the standard surgical procedure for patients with solid-type clinical stage IA NSCLC.