Author of

• 10850

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  P1.12 - Poster Session 1 - NSCLC Early Stage (ID 203)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Medical Oncology
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10852

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    P1.12-002 - The clinicopathological features of resected peripheral squamous cell carcinomas of the lung: Prognostic impact of vascular and pleural invasion (ID 756)

    09:30 - 09:30  |  Author(s): T. Kinoshita
    • Abstract

    Background
    Although the incidence of peripheral squamous cell carcinomas (SqCCs) of the lung has increased over recent years, clinicopathological factors influencing prognosis of resected peripheral lung SqCCs remain to be elucidated.

    Methods
    We reviewed the clinical data of 186 patients who underwent complete resection of peripheral lung SqCCs in our institute and analyzed the clinicopathological features in relation to their overall survival (OS) and recurrence free survival (RFS).

    Results
    The enrolled patients ranged in age 40 to 91 years, with a median age of 69 years. Multivariate analysis revealed that nodal metastasis (OS; Hazard ratio (HR) = 2.47, P = 0.02), vascular invasion (OS; HR = 1.93, P < 0.05, RFS; HR = 2.07, P = 0.01) and pleural invasion (OS; HR = 2.27, P = 0.02, RFS; HR = 2.30, P < 0.01) were independent unfavorable prognostic factors. Among pathologically confirmed stage I peripheral SqCCs patients, high serum squamous cell carcinoma antigen (SCC) levels (OS; HR = 3.91, P < 0.01, RFS; HR = 2.30, P < 0.01), vascular invasion (RFS; HR = 2.68, P = 0.02) and pleural invasion (OS; HR = 4.44, P = 0.01, RFS; HR = 4.57, P < 0.01) were strongly correlated with poor prognosis.Figure 1

    Conclusion
    Pleural and vascular invasions were independent poor prognostic factors for completely resected peripheral SqCC. Adjuvant chemotherapy might be beneficial for patients having SqCC with pleural and vascular invasion.