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A. Pierre



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    P1.07 - Poster Session 1 - Surgery (ID 184)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Surgery
    • Presentations: 1
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      P1.07-026 - VATS reduces surgical risk of lobectomy for high risk patients with early non-small cell lung cancer (ID 2039)

      09:30 - 09:30  |  Author(s): A. Pierre

      • Abstract

      Background
      Patients considered to be at increased risk from surgery may be offered nonsurgical therapies for early stage non-small cell lung cancer (NSCLC). However, video assisted thoracic surgery (VATS) is associated with lower morbidity and thus may permit anatomic resection for patients considered increased risk.

      Methods
      Our institutional database was queried to find all patients who received lobectomy for early stage NSCLC between 2002-2010. Patients were grouped into cohorts of standard (SR, n=536) or increased risk (IR, n=72) using the ACOSOG Z4099/RTOG 1021 eligibility criteria. Morbidity and mortality were compared based on risk group and surgical method.

      Results
      Median age was 72 and 67 years for IR and SR respectively. Most patients were stage I (IR: 83.3%; SR: 84.5%). Although IR patients had increased overall and pulmonary complications compared to SR (overall: p=0.0004; pulmonary: p<0.0001), there were no differences between the subset of IR patients who had VATS resections and SR patients resected by either open or VATS techniques (overall: p=0.7697; pulmonary: p=0.3219) [Table 1]. Survival at 5 years was significantly lower for IR patients resected by open techniques (46.2%; p=0.0028) but those resected by VATS (61.2%) had similar survival to SR patients resected by either VATS (65.1%) or open techniques (64.3%; p=0.83) [Figure 1]. There was no significant difference in operative mortality between the IR and SR groups (IR: 1.4%; SR: 0.4%; p=0.2832).

      Table 1: Post-operative complications stratified by risk subgroup and surgical method
      Increased risk (%) Standard Risk (%) Increased Risk with VATS resection (%)
      Overall Complications 33.3 16.2 18.2
      Pulmonary Complications 30.6 11.8 18.2
      Figure 1 Figure 1: Overall survival following lobectomy for NSCLC, stratified by risk group and surgical method

      Conclusion
      Surgical morbidity and mortality are reduced in patients at increased risk from lobectomy when resected by VATS offering them equivalent outcomes to standard risk patients.

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    P1.22 - Poster Session 1 - Epidemiology, Etiology (ID 166)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Prevention & Epidemiology
    • Presentations: 1
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      P1.22-011 - Assessment of the accuracy and reliability of health related behavioural data obtained from patient-reported surveys (PRS) compared with electronic patient records (EPR) in lung cancer patient population (ID 2948)

      09:30 - 09:30  |  Author(s): A. Pierre

      • Abstract

      Background
      Cigarette smoking, alcohol consumption and presence of co morbidities are important factors that affect health status and mortality in patients diagnosed with lung cancer. While the gold standard for presence or absence of co-morbidities is EPR, the gold standard for obtaining accurate data pertaining to health-related behaviours is by PRS. The purpose of this study is to ascertain, whether in the absence of patient self-reported data, health related behavioural data pertaining to cigarette smoking and alcohol consumption abstracted from EPR provides an accurate and reliable surrogate.

      Methods
      731 lung cancer patients completed a PRS pertaining to information on their lifetime tobacco use, alcohol consumption and whether or not they had been diagnosed with certain co-morbid conditions. Relevant smoking, alcohol consumption and co-morbidity data was collected independently from EPR. Kappa coefficient analysis was used to assess the agreement.

      Results
      Results can be seen in Table 1. Ever/never status for smoking showed almost perfect agreement (k=0.95) between PRS and EPR and surpassed all other health behavioural measures and all co-morbidity agreement values. The calculation of pack-years from EPR and PRS showed substantial agreement (k=0.77); However, categorizing the smoking status into current/ former / never, resulted in only moderate agreement (k=0.47). Alcohol ever/ never status agreement was moderate (0.44) with high sensitivity (0.90) but low specificity (0.50). The lung related co-morbidities like emphysema (k=0.41) and chronic bronchitis (k=0.28) showed fair agreement but with substantial missing data through EPR.

      Table 1
      Health Behaviour N Missing Data in EPR Agreement (k) 95% CI (P value) Se Sp
      Smoking (E/N) 709 0 0.95 (0.79, 0.89) 0.995 0.94
      Smoking (Pkyrs)* 606 81(11%) 0.77 P<0.0001
      Smoking (C/F/N)** 705 4(0.5%) 0.47 (0.41, 0.51)
      Alcohol (E/N) 575 150(20.5%) 0.44 (0.36, 0.52) 0.9 0.5
      Comorbidity
      Emphysema 589 126(17.2%) 0.41 (0.33, 0.49) 0.41 0.95
      Chronic Bronchitis 601 94(12.8%) 0.28 (0.19, 0.37) 0.39 0.88
      *Spearman correlation coefficient
      **Weighted kappa

      Conclusion
      In the absence of PRS data, EPR provides a reliable surrogate for ever/ never smoking status and moderately reliable for lifetime smoking exposure in this lung cancer population. However current/ former/ never smoking status and ever/ never alcohol status cannot be reliably ascertained from medical records. Missing EPR data related to smoking pack years, alcohol consumption and lung co-morbidities is concerning and suggests more systematic or synoptic reporting by physicians would improve opportunities for research