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  P3.11 - Poster Session/ Palliative and Supportive Care (ID 231)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Palliative and Supportive Care
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15617

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    P3.11-001 - Hypertension Associated with Venous Thromboembolism in Patients with Lung Cancer (ID 336)

    09:30 - 09:30  |  Author(s): Z. Zhai
    • Abstract
    • Slides

    Background:
    Patients with lung cancer are at increased risk of venous thromboembolism (VTE). Patient-related factors may help estimate an individual’s risk for VTE. Cardiovascular disease (CVD) risk factors increase the risk of arterial embolism, but it is less clear whether these factors increase the risk of VTE associated with lung cancer.We evaluated associations between major CVD risk factors and the occurrence of VTE in lung cancer patients using data from the Lung Cancer and Thrombosis Study conducted by the China VTE Study Group.
    
    Methods:
    A total of 632 hospitalized patients with newly diagnosed lung cancer were screened for VTE, and their major CVD risk factors were assessed at the baseline examination. Additionally, VTE diagnoses within the three months prior to recruitment were reviewed.
    
    Results:
    Eighty-six of the 632 (13.6%) experienced a VTE event, and 7.8%, 3.3%, and 16.6% of the patients also experienced diabetes, dyslipidemia and hypertension, respectively. Hypertension was more frequent in patients with VTE than in those without VTE (24.4% vs. 15.4%, P=0.04). Multivariate logistic regression analysis, including age, sex, smoking, body mass index, diabetes, dyslipidemia, hypertension and white blood cell count, found that hypertension (odds ratio [OR] 1.8; 95% CI 1.0-3.3; P=0.041) and leukocytosis (OR 2.7; 95% CI 1.5-4.8; P=0.001) were significantly associated with VTE in different tumor histology models and that hypertension (OR 1.9; 95% CI 1.1-3.4; P=0.029) and leukocytosis (OR 2.7; 95% CI 1.5-4.7; P=0.001) were also significantly associated with VTE in different tumor stage models. Leukocytosis was linearly associated with hypertension and VTE (P for trend = 0.006), and the ORs for VTE increased with leukocytosis (all P for trend < 0.05).
    
    Conclusion:
    Hypertension was associated with the risk of VTE in patients with newly diagnosed lung cancer, which may be mediated by the presence of inflammation.
    
    

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