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T. Ohara
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P3.08 - Poster Session/ Thymoma, Mesothelioma and Other Thoracic Malignancies (ID 226)
- Event: WCLC 2015
- Type: Poster
- Track: Thymoma, Mesothelioma and Other Thoracic Malignancies
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.08-023 - Evaluation of Multiple Time Resection of Lung Metastases from Colorectal Cancer (ID 394)
09:30 - 09:30 | Author(s): T. Ohara
- Abstract
Background:
Surgical resection of lung metastasis from colorectal cancer is beneficial for improving the prognosis of patients when no other metastatic lesions exist. However, the efficiency of multiple time resection of lung metastases has not yet been established. We investigated the characteristics and prognosis of multi-time lung resection cases in order to identify the appropriate indication for this procedure.
Methods:
Ninety-nine patients underwent resection of lung metastases from colorectal cancer between 1993 and 2013 at our institute. Among these patients, we investigated 26 cases who underwent lung resection more than twice.
Results:
With regard to the initial stage of disease, one case was stage I, 4 were stage II, 15 were stage III, and 6 were stage IV. Twenty-two patients underwent lung resection twice, and 4 patients underwent lung resection three times. The median follow-up time was 85 months (range, 36–215 months). Twelve cases died of colorectal cancer recurrence. Eight cases died due to metastases to multiple organs including the liver, lymph nodes, and lung. Two cases died of multiple lung metastases, one died of liver metastasis, and one died of mediastinal nodal metastasis. The overall survival curve from second lung resection is shown in the figure (Kaplan-Meier curve, log-rank test). The 5-year overall survival rate was 46.2%, and the 5-year disease-free survival rate was 44.1%. Three out of 4 cases who underwent lung resection three times died within a year after the operation. Figure 1
Conclusion:
A second lung resection seems to be feasible, while a third may not. Precise evaluation of metastatic lesions in other organs before operation and systemic therapy for preventing multiple metastases may be important.
