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R. Shimizu
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P3.06 - Poster Session/ Screening and Early Detection (ID 220)
- Event: WCLC 2015
- Type: Poster
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.06-027 - Stage and Histology Specific Differences in Patterns of Recurrence in Early Stage and Locally Advanced Non-Small Cell Lung Cancer (ID 2437)
09:30 - 09:30 | Author(s): R. Shimizu
- Abstract
Background:
Various guidelines have proposed continuous surveillance for non-small cell lung cancer (NSCLC) after curative therapy. Yet the optimal postoperative surveillance strategy remains unclear.
Methods:
Patients who underwent complete resection for stage I-IIIA NSCLC were analyzed. Complete resection was defined as lobectomy and lobe-specific systematic nodal resection or more. We compared patterns of recurrence in patients with histology and early stage vs locally advanced NSCLC.
Results:
From 2002 to 2010, 745 patients were identified. 106 of 625 patients (17%) with stage I-II NSCLC and 74 of 120 patients (62%) with stage IIIA NSCLC developed recurrences. Local recurrences were significantly frequent in stage IIIA patients (45 [61%] vs 29 [27%] for stage I-II patients), whereas distant recurrences were about the same frequency in stage I-II and IIIA patients (91 [86%] vs 64 [86%]). Approximately 90% of recurrences had occurred within 3 years after surgery and recurrence rate within first year was significantly higher in stage IIIA patients (51 [69%] vs 52 [49%] for stage I-II patients; p=0.008). Squamous cell carcinoma (SqCC) patients had tendency to relapse earlier than non-SqCC patients (Figure 1). In particular, all recurrences in stage IIIA-SqCC patients had occurred within first 2 years . Although the risk of recurrence in stage IIIA patients was highest in the first 2 years, it remained consequential up to 6 years after surgery (Figure 2). Figure 1 Figure 2
Conclusion:
Stage IIIA NSCLC patients had significantly higher risk of recurrence and this risk was continued to 6 years after surgery. SqCC patients had tended to recur earlier. Surveillance strategies may need to account for stage- and histology-specific differences.
