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D.S. Heo
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P3.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 235)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.04-117 - Clinical Characteristics and Survival Outcome of Non-Small Cell Lung Cancer According to Age (ID 2522)
09:30 - 09:30 | Author(s): D.S. Heo
- Abstract
Background:
Clinical characteristics of non-small cell lung cancer (NSCLC) in young age are different from those of older patients. The aim of this study was to compare the survival according to age with adjustment for major confounding factors including major drugable mutations (EGFR and ALK).
Methods:
From June 2011 to December 2014, 1860 consecutive newly diagnosed NSCLC patients were recruited. Among them, we divided 4 groups according to age; group I (age<40), group II (40≤age<60), group III (60≤age<80), and group IV (age>80). We compared survival using 3 different Cox proportional hazard model; unadjusted model, model 1 (adjusted for sex, smoking, BMI, ECOG performance status, histology of adenocarcinoma, initial stage), and model 2 (model 1 + drugable mutations).
Results:
Among 1860 patients, mean age was 66.1 years old, and 64.7% was male. Never smokers were 38.0% and adenocarcinoma observed in 62.0%. EGFR and ALK mutations were detected in 40.3% and 5.1%, respectively. The numbers of patients were 29 in group I, 436 in group II, 1276 in group III, and 119 in group IV. In Cox proportional hazard model, survival differences between age groups were significant in unadjusted model and model 1. But after adjustment for drugable mutations (model 2), the survival difference was not significant.
Conclusion:
Survival on NSCLC in young age was not different from that older patients, after adjustment for sex, smoking, BMI, ECOG performance status, histology of adenocarcinoma, initial stage and major drugable mutations (EGFR and ALK).
