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H. Song
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-031 - Patient Outcomes following Curative-Intent Lung Resection among Non-Small Cell Lung Cancer (NSCLC) Patients in China (ID 2559)
09:30 - 09:30 | Author(s): H. Song
- Abstract
Background:
Lung resection is a common treatment for patients with non-small cell lung cancer (NSCLC), particularly those with early stage disease. This study aimed to assess patient short-term outcomes following curative-intent lung resection among patients with NSCLC.
Methods:
Data were obtained from an NSCLC surgical outcome registry, which included patients from 13 tertiary hospitals in 11 provinces in 2013 and 2014. The surgery types include thoracotomy, video-assisted thoracic surgery (VATS), conversion from thoracotomy to VATS and mini-thoracotomy under VATS. Among all patients, 1,071 were followed up for at least 6 months. Post-surgery treatment pattern and patient outcomes (surgical complication rate and rates of survival, new metastasis and recurrent at the 6-month follow-up) were described; patient outcomes were compared among different tumor stages using Fisher’s exact test.
Results:
Among the 1,071 patients with ≥ 6-month follow up, the median age was 60 (range 26 to 84) years old and 68.3% were male. The most common types of cancer were adenocarcinoma (56.1%) and squamous cell carcinoma (38.3%). Based on the pathologic staging, 42.3% patients had stage I tumor; and stage II, III and IV tumor accounted for 27.5%, 27.8% and 2.4% of the patients, respectively. After surgery, 57.9% patients received further treatment: most of them received chemotherapy (78.3%), 1.2% received targeted therapy, 1.2% received radiation, 0.3% received re-operation, 7.2% received alternative medicine treatment. The overall post-surgery complication rate following surgeries was 6.0% and it did not vary significantly by stage (5.1%, 5.4%, 9.4% and 9.5% for stage I-IV, respectively; p=0.122). The overall survival rate at 6 months was 96.2% and it decreased substantially with increasing stage (98.3%, 95.4%, 92.2% and 85.7% for stage I-IV, respectively; p=0.0005). Recurrence rate was 1.5% for all patients and it was substantially higher among patients with stage IV cancer (2.2 %, 1.7%, 0.4% and 10.0% for stage I-IV, respectively; p=0.032). New metastasis occurred in 6.4% patients. Again, the rate varied significantly across different stages (4.9%, 4.2%, 10.0% and 25.0% for stage I-IV, respectively; p=0.001).
Conclusion:
Chemotherapy was the most commonly used treatment after surgery for NSCLC patients. Additionally, the NSCLC patients who underwent curative-intent lung resection surgeries had relatively high survival rate, low rates of recurrence and new metastasis at the 6-month follow up. As expected, prognosis became worse with increasing tumor stage.
