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D. Taniguchi
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-023 - Surgical Outcomes of Lung Cancer Combined With Interstitial Pneumonia. - Single Institutional Report - (ID 1102)
09:30 - 09:30 | Author(s): D. Taniguchi
- Abstract
Background:
Several studies have reported that acute exacervation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection for patients with non-small cell lung cancer (NSCLC), though the strategy of the perioperative management is controversial.
Methods:
We examined our institutional data about the lung cancer patients from June 1994 through October 2013 at Nagasaki University Hospital in a retrospective manner.
Results:
A total of patients who underwent lung resection for NSCLC(1701 cases) was investigated, 58 had IIP, for an incidence rate of 3.8%. The majority of patients were men (52 cases, 89.6%) and ex- or current smokers (53 cases, 91.3%), and the average of Packs per year was 54.1 (range 30-150). Squamous cell carcinoma was the most common type of lung cancer (23 cases, 39.6%), and the second common type was adenocarcinoma (22 cases, 37.9%). Surgical procedure was wedge resection in 12 cases, segmentectomy in 6 cases, lobectomy in 39 cases, pneumonectomy in 1 case, respectively. 6 cases(10.3%) had AE of IIP following lung resection, 3 cases(50%) of those patient died in the hospital. The univariate analysis and multivariate analysis were carried out to identify possible risk factors for AE. The univariate analysis identified LDH and bleeding amount. Multivariate analysis further identified only LDH. As a treatment for AE, we performed steroid pulse therapy and administration of Neutrophil elastase inhibitor. In some cases that no effect was given by such treatments, we performed direct hemoperfusion with a polymyxin B immobilized fiber column and administered immunosuppressant.
Conclusion:
Patients with lung cancer combined with IIP increases the risk of chest surgery, and the prognosis of them is poor. Because the prediction of AE is often difficult, surgery and perioperative management should be done very carefully.
