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E. Brandén
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-019 - Surgery in Elderly Patients ( > 70 Years or Older) with Non-Small Lung Cancer (NSCLC). Impact of Adjuvant Chemotherapy (ID 2243)
09:30 - 09:30 | Author(s): E. Brandén
- Abstract
Background:
Surgery remains the cornerstone of therapy for medically operable patients with early stage NSCLC. Differences in the frequency of surgery for patients with respect to their age, sex and socioeconomic deprivation have been described. Older patients have been found to be less likely to undergo surgery compared with younger patients even when they have similar performance status. Several randomized trials and meta-analyses have shown that adjuvant chemotherapy after resection of stages II–IIIA NSCLC improves survival.
Methods:
The medical records of all 164 patients ≥70 years, who underwent surgery for NSCLC from 2003 to 2009 at our department, were reviewed retrospectively.
Results:
One-hundred twenty-six given no adjuvant therapy. Eigthy-seven (52.4%) were male. Median mean and range of age male patients was 75.0, 74.8 and 70-85 years, while in females, these figures were 74.0, 75.5 and 70-84 years. Eighty-one (94.2%) of the males and 65 (82.3%) of the females were smoker/former-smoker. In both sexes 99% had performance status 0-1. Eighty-one (93.1%) of male patients and 71 (89.9%) of the females were stage I-II. Adenocarcinoma was the common histology in both sexes (55% of the males and 67.1% of the females). Squamous cell carcinoma came in second place, 31% respectively 20%. Lobectomi performed in 61 (84.1%) of the male patients and 62 (86.2%) female patients, left pneumonectomy in 6 (7.3%) male patients and 5 (6.9%) in female patients, right pneumonectomy in 1(1.4%) female patient. One-hundred twenty-six (77%) did not receive adjuvant therapy, mainly because of age. Median overall survival among all was 7.2 years, in the non-adjuvant group was 6.7 years and 7.6 years in the adjuvant group (p=0.5712).
Conclusion:
This single-institution series demonstrates that surgical intervention for appropriately selected elderly patients with NSCLC results in improved overall survival. Surgery should, therefore, be strongly considered for select patients ≥ 70 years of age with stage I/II and select stage IIIA NSCLC who have adequate pulmonary reserve.
