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D. Lee
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P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)
- Event: WCLC 2015
- Type: Poster
- Track: Treatment of Localized Disease - NSCLC
- Presentations: 1
- Moderators:
- Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P3.02-005 - Third Primary Lung Cancers: Incidence and Benefits of Surgical Therapy (ID 1688)
09:30 - 09:30 | Author(s): D. Lee
- Abstract
Background:
Continued surveillance of lung cancer patients after curative surgery allows for the diagnosis of new disease. However, there is a relative paucity of data in regards to the development of third primary lung cancers. The goals of this study were to examine the incidence of third primary cancers and the results of surgical therapy.
Methods:
Surgically resected Stage 1 second primary lung cancers with complete data were identified in The Survival Epidemiology and End Results (SEER) database between 2004 and 2010. Among these 238 cases, those which developed a third primary lung cancer 6 or more months after the diagnosis of the second primary were analyzed. Statistical methods were performed using Kaplan-Meier and multivariate analysis. A p value < 0.05 was considered statistically considered significant.
Results:
Twenty-four patients (10.1%) experienced a third primary lung cancer; sixteen cases (66.7%) were diagnosed in stage I. Twelve patients (50% of cases) underwent cancer surgery. Nine patients (37.5%) were treated with beam radiation – alone (8 cases, 89%) or in combination with surgery (1 case, 11%). Surgery was performed more frequently in early stages (75% of surgical cases were stage I versus 58% of non-surgical cases). There was no difference in age between patients who underwent any treatment and those who did not. Length of follow-up in third primary cancers was 18 months if surgically treated and 8 months if not surgically treated (p < 0.02). At multivariate analysis, the only independent predictor of improved survival was treatment (Hazard ratio (HR) 0.21, 95% CI: 0.07-0.66; p=0.007). Both surgery (HR=0.02; 95% CI: 0.002-0.29) and radiation (HR= 0.04; 95% CI: 0.002-0.54) significantly improved survival. Figure 1
Conclusion:
The overall incidence of third primary lung cancers after a second primary is 10.1%. Surveillance and intervention at early stage results in improved survival.
