Author of

• 15301

  +

  P3.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 211)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Treatment of Localized Disease - NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/09/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 15304

    +

    P3.02-003 - Availability of the Serum CYFRA 21-1 Level with Resected Non-Small Cell Lung Cancer: The Detectability of Recurrence and the Prognostic Impact (ID 3233)

    09:30 - 09:30  |  Author(s): M. Suzuki
    • Abstract
    • Slides

    Background:
    The appropriate protocol of postoperative surveillance for patients with non-small cell lung cancer (NSCLC) is still controversial. The aim of this study is to evaluate the detectability of recurrence and the prognostic impact of the serum CYFRA 21-1 levels.
    
    Methods:
    We retrospectively reviewed 1076 patients who underwent surgical resection for NSCLC at Juntendo University Hospital, between January 2008 and May 2013. Patients with renal dysfunction were excluded.
    
    Results:
    Recurrence developed in 47 patients (30.5%) in high preoperative serum CYFRA 21-1 group, and 147 patients (16.0%) in normal preoperative serum CYFRA 21-1 group. High preoperative serum CYFRA 21-1 was related to the high recurrence rate (p<.0001) and the poor prognosis (p<.0001). In high preoperative serum CYFRA 21-1 group, 111 patients measured the serum CYFRA 21-1 level within the 1-3 months after surgery. Among them, 31 patients (27.9%) had an elevated serum CYFRA 21-1 level, and the poor prognosis (p<.0001) (Fig.). In 94 patients who measured the serum CYFRA 21-1 level during the follow-up period, 35 patients (37.2%) could detect recurrence by an elevated serum CYFRA 21-1 level before recurrence. Only for high preoperative serum CYFRA 21-1 group, 23 patients (67.6%) could detect recurrence.
    
    Conclusion:
    High preoperative serum CYFRA 21-1 was related to the high recurrence rate and the poor prognosis. In addition, high early-postoperative (1-3 months after surgery) serum CYFRA 21-1 was related to the poor prognosis. Measuring the serum CYFRA 21-1 level during the follow-up period is useful in the detection of recurrence, but that rate is low.
    
    

    Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.